ArticleFrontiers in pediatrics2026
Development and internal validation of a nomogram for early prediction of hospital-acquired ESKAPE colonization or infection in very preterm infants using indicators available within 24 hours.
Article in Frontiers in pediatrics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: ESKAPE pathogens are a major cause of hospital-acquired colonization or infection among very preterm infants in neonatal intensive care units ( Methods: A single-center retrospective cohort study was conducted among 465 very preterm infants (gestational age, GA ≤ 32 weeks) admitted to the NICU of a tertiary hospital between January 2015 and June 2025. Infants were randomly divided into training ( Results: Overall, 77 infants (16.56%) developed hospital-acquired ESKAPE colonization or infection, of which 67.5% (52/77) were first identified within 14 days after birth. Among 109 non-duplicate ESKAPE isolates, the predominant pathogens were Conclusion: We developed and internally validated a nomogram for early prediction of hospital-acquired ESKAPE colonization or infection in very preterm infants using routine clinical indicators obtained within 24 h after birth. The model can support early risk stratification and infection control prioritization in the NICU. External validation and prospective implementation studies are required before routine clinical adoption.
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