Evidence map›Paper›PMID 42339276›Full record

ArticleRSC medicinal chemistry2026

3-Hydroxypyrimidine-2,4-dione derivatives as monkeypox virus resolvase (Mpr) inhibitors.

Muhammad Syafiq Bin Shahari, Jacob P Mahoney, Ziyue Wang, Anil Pant, Ajit Jagtap, Roshan Katekar, Jiashu Xie, Zhilong Yang, Zhengqiang Wang

Abstract read
In one paragraph

Article in RSC medicinal chemistry, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Muhammad Syafiq Bin ShahariCenter for Drug Design, College of Pharmacy, University of Minnesota Minneapolis Minnesota 55455 USA wangx472@umn.edu +1 (612) 626 7025.
Jacob P MahoneyCenter for Drug Design, College of Pharmacy, University of Minnesota Minneapolis Minnesota 55455 USA wangx472@umn.edu +1 (612) 626 7025.ORCID https://orcid.org/0000-0002-7174-9161
Ziyue WangDepartment of Veterinary Pathobiology, College of Veterinary Medicine & Biomedical Sciences, Texas A&M University College Station Texas 77843 USA.
Anil PantDepartment of Veterinary Pathobiology, College of Veterinary Medicine & Biomedical Sciences, Texas A&M University College Station Texas 77843 USA.
Ajit JagtapCenter for Drug Design, College of Pharmacy, University of Minnesota Minneapolis Minnesota 55455 USA wangx472@umn.edu +1 (612) 626 7025.
Roshan KatekarCenter for Drug Design, College of Pharmacy, University of Minnesota Minneapolis Minnesota 55455 USA wangx472@umn.edu +1 (612) 626 7025.
Jiashu XieCenter for Drug Design, College of Pharmacy, University of Minnesota Minneapolis Minnesota 55455 USA wangx472@umn.edu +1 (612) 626 7025.
Zhilong YangDepartment of Veterinary Pathobiology, College of Veterinary Medicine & Biomedical Sciences, Texas A&M University College Station Texas 77843 USA.
Zhengqiang WangCenter for Drug Design, College of Pharmacy, University of Minnesota Minneapolis Minnesota 55455 USA wangx472@umn.edu +1 (612) 626 7025.ORCID https://orcid.org/0000-0002-1326-5986

Funding

Development of novel antivirals against mpox (monkeypox) virusR01AI183580 · NIAID · UNIVERSITY OF MINNESOTA · PI Zhengqiang Wang, Zhilong Yang · 2024 to 2026
$2.3M
NIAID NIH HHS R01 AI183580
6 · The paper itself

Abstract

Holliday junction resolvase plays an important role in poxvirus genome replication and viral maturation. Recently, we developed the first

Identifiers

PMID42339276
PMCPMC13286028

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.