Evidence map›Paper›PMID 42339118›Full record

ArticleFrontiers in oncology2026

Digital Twins as catalysts for Whole Person Health Mind Body Medicine in Integrative Oncology.

Claudia M Witt

Abstract read
In one paragraph

Article in Frontiers in oncology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

1 author.

Claudia M WittComplementary and Integrative Digital Health Institute of Primary Care, University of Zurich and University Hospital Zurich, Zurich, Switzerland.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Artificial intelligence and digital health technologies are reshaping oncology through increasingly personalized, predictive, and data-driven care. Among these innovations, medical Digital Twins - dynamic virtual software representations of individual patients - are emerging as tools for simulating disease trajectories, forecasting treatment responses, and supporting clinical decision-making. To date, most oncology focused Digital Twin research centers on tumor biology, imaging, genomics, radiotherapy optimization, and treatment response. Integrative Oncology requires a broader perspective. As a patient-centered field that emphasizes Whole Person Health across prevention, treatment, rehabilitation, survivorship, and long-term health promotion, Integrative Oncology depends on biological, behavioral, psychosocial, environmental, and lifestyle-related data that remain underrepresented in digital health infrastructures. This paper argues that Digital Twins could advance Whole Person Health in Integrative Oncology if they are designed to integrate not only disease- and treatment-related data but also key domains of Mind Body Medicine, including physical activity, diet, sleep, stress regulation, self-care, social and other relationships, living conditions, and personal preferences. Drawing on a SWOT analysis and a Whole Person Health Mind Body Medicine model, the paper identifies strengths and opportunities, including personalization, longitudinal monitoring, treatment coordination, and adaptive self-care support. It also highlights challenges related to data quality, interoperability, digital literacy, privacy, autonomy, equity, and reductionist interpretations of health. The central challenge is therefore not only technological but preparatory. Integrative Oncology must actively contribute to interoperable data standards, ethical governance, clinical validation, and interdisciplinary collaboration to ensure that future Digital Twins support, rather than marginalize, whole person, human-centered cancer care.

Indexed as

AIartificial intelligenceDigital Twinintegrative oncologyMind Body MedicineWhole Person Health

Identifiers

PMID42339118
PMCPMC13283834

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.