Evidence map›Paper›PMID 42339083›Full record

ArticleFrontiers in endocrinology2026

The impact of regressed endometrial hyperplasia on reproductive outcomes following frozen embryo transfer: a propensity score-matched cohort study.

Qinling Zhu, Lizhen Xu, Bing Xu, Yao Lu, Zhe Wei, Wenchao Zhang, Yiwen Meng, Chongwen Shao, Mengjia Shi, Yaqiong He and 5 more

Abstract read
In one paragraph

Article in Frontiers in endocrinology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Qinling Zhu *Department of Reproductive Medicine, Shanghai Key Laboratory for Assisted Reproduction and Reproductive Genetics, Ren Ji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Lizhen Xu *Department of Reproductive Medicine, Shanghai Key Laboratory for Assisted Reproduction and Reproductive Genetics, Ren Ji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Bing XuDepartment of Reproductive Medicine, Shanghai Key Laboratory for Assisted Reproduction and Reproductive Genetics, Ren Ji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Yao LuDepartment of Reproductive Medicine, Shanghai Key Laboratory for Assisted Reproduction and Reproductive Genetics, Ren Ji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Zhe WeiDepartment of Reproductive Medicine, Shanghai Key Laboratory for Assisted Reproduction and Reproductive Genetics, Ren Ji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Wenchao ZhangDepartment of Reproductive Medicine, Shanghai Key Laboratory for Assisted Reproduction and Reproductive Genetics, Ren Ji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Yiwen MengDepartment of Reproductive Medicine, Shanghai Key Laboratory for Assisted Reproduction and Reproductive Genetics, Ren Ji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Chongwen ShaoDepartment of Reproductive Medicine, Shanghai Key Laboratory for Assisted Reproduction and Reproductive Genetics, Ren Ji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Mengjia ShiDepartment of Reproductive Medicine, Shanghai Key Laboratory for Assisted Reproduction and Reproductive Genetics, Ren Ji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Yaqiong HeDepartment of Reproductive Medicine, Shanghai Key Laboratory for Assisted Reproduction and Reproductive Genetics, Ren Ji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Jiangan HuangDepartment of Reproductive Medicine, Shanghai Key Laboratory for Assisted Reproduction and Reproductive Genetics, Ren Ji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Yuan WangDepartment of Reproductive Medicine, Shanghai Key Laboratory for Assisted Reproduction and Reproductive Genetics, Ren Ji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Jia QiDepartment of Reproductive Medicine, Shanghai Key Laboratory for Assisted Reproduction and Reproductive Genetics, Ren Ji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Ying DingDepartment of Reproductive Medicine, Shanghai Key Laboratory for Assisted Reproduction and Reproductive Genetics, Ren Ji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Yun SunDepartment of Reproductive Medicine, Shanghai Key Laboratory for Assisted Reproduction and Reproductive Genetics, Ren Ji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Purpose: To investigate the impact of regressed endometrial hyperplasia (EH) on assisted reproductive technology outcomes, particularly in comparison with infertile women with a relatively normal endometrium. Methods: This retrospective study included 95 patients with EH regression after conservative treatment and 30634 infertile controls at the Reproductive Medicine Center from January 2015 to December 2022. Propensity score matching was performed at a ratio of 1:4 between EH and control patients following first frozen embryo transfer. Pregnancy, obstetric and neonatal outcomes were compared between matched pairs. Subgroup analysis was performed between EH patients with and without atypia. Binary logistic regression was conducted to identify risk factors for live birth among EH patients. The primary outcome was live birth rate. Results: Compared with matched controls, patients with EH exhibited a significantly lower live birth rate (31.6% vs. 49.2%, Conclusions: Even after complete remission, EH remained associated with a reduced likelihood of live birth following FET. Prolonged progesterone therapy and delayed remission further diminished the live birth likelihood, highlighting the need for optimized treatment and individualized conception counseling in this high-risk population.

Indexed as

Embryo TransferEndometrial HyperplasiaInfertility, FemaleAdultCryopreservationFemaleHumansLive BirthPregnancyPregnancy OutcomePregnancy RatePropensity ScoreRetrospective Studiesconservative treatmentendometrial hyperplasiafrozen embryo transferlive birthpropensity score matching

Identifiers

PMID42339083
PMCPMC13283882

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.