ArticleInfection and drug resistance2026
Effect of Early Administration of Casirivimab and Imdevimab in Hospitalized Patients with COVID-19: A Post Hoc Analysis.
Article in Infection and drug resistance, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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7 authors.
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Abstract
Purpose: Casirivimab and imdevimab (CAS+IMD) has been shown to improve clinical outcomes (death/mechanical ventilation) in seronegative hospitalized patients with COVID-19. The objective of the current analysis was to assess whether time to administration of CAS+IMD, from the start of COVID-19 symptoms, influenced these outcomes. Patients and Methods: This was a post hoc analysis of Study 2066 (conducted between 10 June 2020 and 9 April 2021), a Phase I/II/III trial investigating the safety and efficacy of CAS+IMD (single intravenous dose) vs placebo in hospitalized adult patients with COVID-19. The primary outcome in this analysis was death or mechanical ventilation. Two populations of patients were assessed: efficacy (n = 738) and exploratory (full analysis set-exploratory data analysis [FAS-EDA]; n = 1115). Time to administration was defined as the number of days of COVID-19 prior to treatment, 4 days being the first quartile, which was considered early treatment administration of CAS+IMD. Results: Odds of death or mechanical ventilation were higher in those aged 50-70 years (odds ratio [OR]: 2.98; 95% confidence interval [CI], 1.62-5.91; Conclusion: Early monoclonal antibody treatment is associated with better outcomes in hospitalized patients with severe COVID-19.
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