ArticleJournal of conservative dentistry and endodontics2026
Assessment of transradicular diffusion of different intracanal medicaments through root dentin and cementum: An
Article in Journal of conservative dentistry and endodontics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: Endodontic treatment aims at the removal of root canal and periradicular infection; however, endo-perio lesions pose difficulty due to the complex disease process. Aims: To evaluate transradicular release of different intracanal medicaments (ICMs) through human root dentin and cementum using an ultraviolet (UV)-visible spectrophotometer. Materials and Methods: Eighty extracted human mandibular premolars were cleaned, decoronated, and standardized to 12 mm root length. Following access opening and biomechanical preparation, the samples were divided for ICM placement into two groups ( Statistical Analysis: One-way analysis of variance and Tukey's Results: Group 2 showed the highest drug release compared to Group 1. In both the groups, Subgroup D (MTAP) showed the highest drug release, followed by Subgroup C (doxycycline + CHX) and B (Ca(OH) Conclusion: MTAP exhibited the highest drug release both in the presence and in the absence of cementum, followed by doxycycline + CHX, and the absence of cementum enhanced the release of medicaments. Thus, these medicaments can be effectively used in cases of compromised root cementum, such as endo-perio or periapical lesions.
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