ArticleJournal of conservative dentistry and endodontics2026
Comparative evaluation of cytotoxicity and antimicrobial efficacy of a poloxamer 407-based pulp capping agent and mineral trioxide aggregate: An
Article in Journal of conservative dentistry and endodontics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Authors and funding
4 authors.
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Abstract
Background: Vital pulp therapy aims to preserve pulp vitality by using biologically compatible materials with sufficient antimicrobial activity and low cytotoxicity. Poloxamer 407, a thermoresponsive polymer, has attracted interest as a potential carrier for pulp-capping formulations due to its favorable physical, chemical, and biological properties. Aim: To compare the antimicrobial effectiveness and cytotoxicity of a Poloxamer 407-based novel pulp-capping agent against Materials and Methods: A 20% w/v Poloxamer-407 hydrogel-containing Biodentine (Sample A) was prepared as the test formulation. Its antimicrobial activity against Results: The Poloxamer 407-based pulp capping agent showed dose-dependent antimicrobial activity, with greater inhibition of Conclusion: The Poloxamer 407-based pulp capping agent showed improved antimicrobial activity with acceptable cytocompatibility, indicating potential as a pulp-capping material.
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