Evidence map›Paper›PMID 42338793›Full record

ArticleJID innovations : skin science from molecules to population health2026

Optimizing the timing of autologous skin cell suspension after enzymatic debridement of porcine burns: Evaluation with digital image speckle correlation.

Shi Fu, Rachel Bonn, Huiting Luo, Robert Ruzic, Zachery Harris, Erica Heller, Steve McClain, Eugene Jiang, Briman Yang, Miriam Rafailovich and 7 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in JID innovations : skin science from molecules to population health, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Shi FuDepartment of Materials Science and Chemical Engineering, Stony Brook University, Stony Brook, New York, USA.
Rachel BonnDepartment of Emergency Medicine, Renaissance School of Medicine at Stony Brook University, Stony Brook, New York, USA.
Huiting LuoDepartment of Materials Science and Chemical Engineering, Stony Brook University, Stony Brook, New York, USA.
Robert RuzicDepartment of Emergency Medicine, Renaissance School of Medicine at Stony Brook University, Stony Brook, New York, USA.
Zachery HarrisDepartment of Biomedical Engineering, Stony Brook University, Stony Brook, New York, USA.
Erica HellerDepartment of Biomedical Engineering, Stony Brook University, Stony Brook, New York, USA.
Steve McClainDepartment of Emergency Medicine, Renaissance School of Medicine at Stony Brook University, Stony Brook, New York, USA.
Eugene JiangDepartment of Biomedical Engineering, Stony Brook University, Stony Brook, New York, USA.
Briman YangDepartment of Materials Science and Chemical Engineering, Stony Brook University, Stony Brook, New York, USA.
Miriam RafailovichDepartment of Materials Science and Chemical Engineering, Stony Brook University, Stony Brook, New York, USA.
Gurtej SinghDepartment of Surgery, Renaissance School of Medicine at Stony Brook University, Stony Brook, New York, USA.
Steven SandovalDepartment of Surgery, Renaissance School of Medicine at Stony Brook University, Stony Brook, New York, USA.
Marcia SimonDepartment of Oral Biology and Pathology, Stony Brook University, Stony Brook, New York, USA.
Mohammed H ArbabDepartment of Biomedical Engineering, Stony Brook University, Stony Brook, New York, USA.
Rachel BrownleeDivision of Laboratory and Animal Resources, Stony Brook University, Stony Brook, New York, USA.
Lior RosenbergDepartment of Plastic and Reconstructive Surgery, Ben Gurion University, Beer Sheba, Israel.
Adam J SingerDepartment of Emergency Medicine, Renaissance School of Medicine at Stony Brook University, Stony Brook, New York, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Enzymatic debridement preserves viable dermis in deep partial-thickness burns, yet the optimal timing of autologous skin cell suspension (ASCS) delivery remains unclear. We evaluated whether ASCS enhances biomechanical restoration after enzymatic debridement, whether a 24-hour delay alters outcomes, and whether digital image speckle correlation provides a sensitive, noninvasive measure of healing. In a porcine dorsal burn model, wounds were treated with ASCS immediately or 24 hours after enzymatic debridement, with bacitracin serving as control. Digital image speckle correlation measurements quantified force propagation across the wound bed using optical-flow method, whereas histology assessed re-epithelialization and dermal remodeling. Complementary in vitro studies examined cytotoxicity of residual debridement enzyme. ASCS significantly increased the restoration of force propagation compared with bacitracin by day 28 (

Indexed as

Autologous cell therapyDigital image speckle correlationEnzymatic debridementPorcine burn modelWound biomechanics

Identifiers

PMID42338793
PMCPMC13285369

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.