Evidence map›Paper›PMID 42338741›Full record

ReviewFrontiers in psychiatry2026

Astrocytic connexins in alcohol use disorder: mechanisms of neuroinflammation and therapeutic potential.

Esohe Imafidon, Elise Allan-Le, Kafui Dzirasa, S Alex Marshall, Julia Derk

Abstract readReview
In one paragraph

Review in Frontiers in psychiatry, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Esohe ImafidonDepartment of Biological and Biomedical Sciences, North Carolina Central University, Durham, NC, United States.
Elise Allan-LeDepartment of Biological and Biomedical Sciences, North Carolina Central University, Durham, NC, United States.
Kafui DzirasaDepartment of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, NC, United States.
S Alex MarshallDepartment of Biological and Biomedical Sciences, North Carolina Central University, Durham, NC, United States.
Julia DerkDepartment of Biological and Biomedical Sciences, North Carolina Central University, Durham, NC, United States.

Funding

Scientific Mentoring and Research Experiences CoreU54AA030451 · NIAAA · NORTH CAROLINA CENTRAL UNIVERSITY · PI XIAOHE YANG · 2022 to 2026
$6.4M
The Functional Implications of Astrocytic GPCR-signaling on Alcohol AbuseSC1GM139696 · NIGMS · NORTH CAROLINA CENTRAL UNIVERSITY · PI MARSHALL, SIMON ALEXANDER · 2021 to 2024
$1.5M
Feeding the STEM Pipeline with Neuroscientist Trained at an HBCUR25MH129791 · NIMH · NORTH CAROLINA CENTRAL UNIVERSITY · PI Gregory Jay Cole, Wendy Heck Grillo · 2022 to 2026
$1.1M
NIAAA NIH HHS U54 AA030451NIGMS NIH HHS SC1 GM139696NIMH NIH HHS R25 MH129791
6 · The paper itself

Abstract

Astrocytes are critical regulators of brain homeostasis and are known to be disrupted during alcohol use disorder (AUD). Here, we describe what is known about astrocytic dysfunction in AUD and the emerging literature supporting a mechanistic link to connexins in the pathophysiology of this disorder. We integrate what is known in the current literature and highlight areas where a lack of evidence leads to inconclusive interpretations. Overall, this is a comprehensive review of astrocytes and connexins in AUD, providing ideas and insights to basic and clinical audiences interested in pursuing future therapeutic mechanisms in AUD.

Indexed as

alcohol use disorderastrocyteconnexins (Cx)mechanisms of diseaseneuroinflammationtherapeutic potential

Identifiers

PMID42338741
PMCPMC13285180

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.