Evidence map›Paper›PMID 42338690›Full record

ReviewClinical kidney journal2026

Executive summary of the European consensus report on the diagnosis and treatment of monoclonal gammopathy of renal significance.

Ben Sprangers, Camille Cohen, Viviane Gnemmi, Amir Shabaka, Gema Fernandez-Juarez, Dominique van Midden, Eric Steenbergen, Paolo Milani, Marguerite Vignon, Benjamin Wilde and 2 more

Abstract readReview
In one paragraph

Review in Clinical kidney journal, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Ben SprangersDepartment of Nephrology, Ziekenhuis Oost-Limburg, Genk, Belgium, and Department of Immunology and Infection, Biomedical Research Institute, UHasselt, Diepenbeek, Belgium.ORCID https://orcid.org/0000-0003-1314-9675
Camille CohenDepartment of Nephrology, APHP, Hôpital Bichat, Paris, France.
Viviane GnemmiDepartment of Pathology, Lille, France.
Amir ShabakaHospital Universitario La Paz. IdiPAz, Madrid, Spain.
Gema Fernandez-JuarezHospital Universitario La Paz. IdiPAz, Madrid, Spain.
Dominique van MiddenDepartment of Pathology, Radboudumc Nijmegen, The Netherlands.
Eric SteenbergenDepartment of Pathology, Radboudumc Nijmegen, The Netherlands.
Paolo MilaniDepartment of Molecular Medicine, University of Pavia, Pavia, Italy.
Marguerite VignonHopital Cochin, APHP, Paris, France.
Benjamin WildeDepartment of Nephrology, University Hospital Essen, University Duisburg-Essen, Essen, Germany.
Ute HegenbartUniversity Hospital, Amyloidosis Center, HeidelbergGermany.
Jack F WetzelsDepartment of Nephrology, Radboud University Medical Center, Nijmegen, The Netherlands.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

We introduce the European Union consensus report on the diagnosis and treatment of monoclonal gammopathy of renal significance (MGRS), a generic term to describe kidney disorders caused by a non-malignant monoclonal immunoglobulin clone. There are many subtypes of MGRS, with AL-amyloidosis being most prevalent. The consensus report aims at providing guidance to clinicians, pathologists and laboratory specialists who take care of patients with a (suspected) diagnosis of MGRS. This executive summary provides a condensed overview of the most important aspects of the diagnosis and management of patients with MGRS. Consultation of expert centers is strongly advised. Although most patients will benefit from hematological, clone-directed therapy, treatment decisions must be individualized, in view of the heterogeneity of patients between and within the MGRS subtypes. The final chapter discusses kidney transplantation in patients with MGRS. The working group acknowledges that most advice is based on low-quality evidence. The full report provides the rationale and a detailed discussion of the available literature. This executive summary is an introduction, and not a substitute for the full consensus report.

Indexed as

AL amyloidosiskidney transplantationMGRSmonoclonal gammopathymonoclonal immunoglobulin deposition disease

Identifiers

PMID42338690
PMCPMC13284707

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.