Evidence map›Paper›PMID 42338605›Full record

ArticleFrontiers in immunology2026

Association of the triglyceride-glucose index with the severity and short-term prognosis of Guillain-Barré syndrome.

Lijuan Wang, Xiang Li, Zikai Zhou, Yuxi Tian, Siwen Li, Wencan Jiang, Kelin Chen, Yuxin Chen, Jie Liu, Guanghui Zheng and 2 more

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Article in Frontiers in immunology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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5 · Who and what money

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12 authors.

Lijuan Wang *Department of Clinical Diagnosis, Laboratory of Beijing Tiantan Hospital, Capital Medical University, Beijing, China.
Xiang Li *Department of Clinical Diagnosis, Laboratory of Beijing Tiantan Hospital, Capital Medical University, Beijing, China.
Zikai Zhou *Department of Clinical Diagnosis, Laboratory of Beijing Tiantan Hospital, Capital Medical University, Beijing, China.
Yuxi TianDepartment of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China.
Siwen LiDepartment of Clinical Diagnosis, Laboratory of Beijing Tiantan Hospital, Capital Medical University, Beijing, China.
Wencan JiangDepartment of Clinical Diagnosis, Laboratory of Beijing Tiantan Hospital, Capital Medical University, Beijing, China.
Kelin ChenDepartment of Clinical Diagnosis, Laboratory of Beijing Tiantan Hospital, Capital Medical University, Beijing, China.
Yuxin ChenDepartment of Clinical Diagnosis, Laboratory of Beijing Tiantan Hospital, Capital Medical University, Beijing, China.
Jie LiuDepartment of Clinical Diagnosis, Laboratory of Beijing Tiantan Hospital, Capital Medical University, Beijing, China.
Guanghui ZhengDepartment of Clinical Diagnosis, Laboratory of Beijing Tiantan Hospital, Capital Medical University, Beijing, China.
Xin Gao WangDepartment of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China.
Guojun ZhangDepartment of Clinical Diagnosis, Laboratory of Beijing Tiantan Hospital, Capital Medical University, Beijing, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Guillain-Barré syndrome (GBS) is a peripheral nerve inflammatory disorder driven by immune-mediated mechanisms. Currently, there is a lack of research investigating the association between the triglyceride-glucose (TyG) index and GBS, and this study sought to explore their possible relationship. Methods: 203 patients with GBS from Beijing Tiantan Hospital were retrospectively enrolled in this study. The relationship of the TyG index with severe and short-term poor prognosis in GBS patients was investigated using least absolute shrinkage and selection operator (LASSO) regression, binary logistic regression, restricted cubic spline (RCS) analysis and receiver operating characteristic (ROC) curve. Results: The TyG index (OR: 2.77; 95% CI: [1.51-5.30]; P = 0.001) was identified as independent risk factors for severe GBS. Conversely, albumin (ALB) (OR: 0.89; 95% CI: [0.82-0.96]; P = 0.006) and the Medical Research Council (MRC) sum score (OR: 0.93; 95% CI: [0.90-0.96]; P<0.001) acted as protective factors. Additionally, the TyG index (OR: 1.85; 95% CI: [1.05-3.32]; P = 0.036) emerged as an independent risk factor for poor short-term prognosis, whereas the MRC sum score (OR: 0.94; 95% CI: [0.91-0.96]; P<0.001) was recognized as a protective factor. Furthermore, TyG index showed a linear correlation with severe GBS (overall P<0.01, nonlinear P = 0.112) and short-term poor prognosis in GBS patients (overall P = 0.068, nonlinear P = 0.277). Used alone, the TyG index yielded area under the curve (AUC) values of 0.644 and 0.589 for predicting severe GBS and short-term poor-prognosis GBS, respectively. When combined with conventional clinical markers, the model achieved an AUC of 0.808 (sensitivity 0.732, specificity 0.776) for severe GBS and 0.765 (sensitivity 0.763, specificity 0.701) for short-term poor prognosis. Bootstrap internal validation showed optimism bias/corrected AUC of 0.008/0.800 and 0.006/0.759 for the two models. After incorporating the TyG index into the baseline model, the net reclassification index (NRI) was significantly elevated, while the integrated discrimination improvement (IDI) showed a slight improvement (all P<0.05). Conclusions: Elevated TyG index is independently linked to higher risks of severe phenotype and short-term poor prognosis in GBS patients. Combined with conventional clinical indicators, TyG index may help predict severe cases and adverse short-term prognosis in GBS.

Indexed as

Blood GlucoseGuillain-Barre SyndromeTriglyceridesAdultAgedBiomarkersFemaleHumansMaleMiddle AgedPrognosisRetrospective StudiesRisk FactorsROC CurveSeverity of Illness IndexBiomarkersBlood GlucoseTriglyceridesbinary logistic regression analysisGuillain-Barré syndromereceiver operating characteristic curvesrestricted cubic splinetriglyceride-glucose index

Identifiers

PMID42338605
PMCPMC13283979

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.