Evidence map›Paper›PMID 42338571›Full record

ArticleMaterials today. Bio2026

Nanoparticle-mediated inhibition of Yes-associated protein prevents corneal scarring after traumatic injury.

Nae-Won Kang, Kyeongwoo Jang, Hyeonji Kim, Li Jiang, Youngyoon Amy Seo, Euisun Song, Julian Garcia-Sanchez, Danting Lin, Fang Chen, Uiyoung Han and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Materials today. Bio, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Nae-Won KangDepartment of Ophthalmology, Spencer Center for Vision Research, Byers Eye Institute, Stanford University, School of Medicine, Palo Alto, CA, United States.
Kyeongwoo JangDepartment of Ophthalmology, Spencer Center for Vision Research, Byers Eye Institute, Stanford University, School of Medicine, Palo Alto, CA, United States.
Hyeonji KimDepartment of Ophthalmology, Spencer Center for Vision Research, Byers Eye Institute, Stanford University, School of Medicine, Palo Alto, CA, United States.
Li JiangDepartment of Ophthalmology, Spencer Center for Vision Research, Byers Eye Institute, Stanford University, School of Medicine, Palo Alto, CA, United States.
Youngyoon Amy SeoDepartment of Ophthalmology, Spencer Center for Vision Research, Byers Eye Institute, Stanford University, School of Medicine, Palo Alto, CA, United States.
Euisun SongDepartment of Ophthalmology, Spencer Center for Vision Research, Byers Eye Institute, Stanford University, School of Medicine, Palo Alto, CA, United States.
Julian Garcia-SanchezDepartment of Ophthalmology, Spencer Center for Vision Research, Byers Eye Institute, Stanford University, School of Medicine, Palo Alto, CA, United States.
Danting LinDepartment of Ophthalmology, Spencer Center for Vision Research, Byers Eye Institute, Stanford University, School of Medicine, Palo Alto, CA, United States.
Fang ChenDepartment of Ophthalmology, Spencer Center for Vision Research, Byers Eye Institute, Stanford University, School of Medicine, Palo Alto, CA, United States.
Uiyoung HanDepartment of Ophthalmology, Spencer Center for Vision Research, Byers Eye Institute, Stanford University, School of Medicine, Palo Alto, CA, United States.
Wendy W LiuDepartment of Ophthalmology, Spencer Center for Vision Research, Byers Eye Institute, Stanford University, School of Medicine, Palo Alto, CA, United States.
David MyungDepartment of Ophthalmology, Spencer Center for Vision Research, Byers Eye Institute, Stanford University, School of Medicine, Palo Alto, CA, United States.

Funding

P30 Core Grant for Vision ResearchP30EY014104 · NEI · MASSACHUSETTS EYE AND EAR INFIRMARY · PI Janey L Wiggs · 2002 to 2026
$15.1M
The Role of Mechanosensitive Ion Channels in GlaucomaK08EY034600 · NEI · STANFORD UNIVERSITY · PI Wendy W. Liu · 2023 to 2026
$964k
NEI NIH HHS K08 EY034600NEI NIH HHS P30 EY014104
6 · The paper itself

Abstract

Corneal scars develop during the regenerative process following traumatic injuries. Verteporfin (VP), a Yes-associated protein (YAP) inhibitor, has shown promise as an antifibrotic agent, but its application to the ocular surface is limited by unfavorable physicochemical properties. Here, we developed the hyaluronic acid-verteporfin nanoparticles (HA-VP NPs) to increase the apparent solubility of VP and prolong residence on the eye, aiming to promote corneal regeneration and prevent scar formation following injuries. The HA-VP NPs effectively prevented not only the transformation of corneal stromal cells into myofibroblasts, but also the epithelial-mesenchymal transition of epithelial cells by inhibiting the translocation of YAP into the nucleus. HA-VP NPs interacted with CD44 receptors, facilitating endocytosis in corneal stromal cells and contributing to prolonged residence time in corneal defects. In a rat anterior lamellar keratoplasty model, the HA-VP NPs were retained on corneal defects for at least 4 h, resulting in excellent corneal regeneration and significant reduction in scarring.

Indexed as

Anti-fibrosisCorneal regenerationOcular nanoparticleOcular residenceVerteporfinYAP inhibition

Identifiers

PMID42338571
PMCPMC13285717

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.