ArticleFrontiers in fungal biology2026
Interplay between CARD9 genetic variants and fungal colonization patterns among patients with diabetes.
Article in Frontiers in fungal biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: Diabetes mellitus significantly increases susceptibility to opportunistic fungal colonization; however, the genetic architecture underlying this vulnerability in Middle Eastern populations remains underexplored. Caspase recruitment domain-containing protein 9 (CARD9) is a fundamental adaptor in fungal sensing. While CARD9 deficiency is traditionally viewed as a rare pediatric immunodeficiency, we hypothesize that common CARD9 variants serve as significant predisposing factors for fungal burden in the adult diabetic population. Methods: A cohort of 107 diabetic participants (49.5% overweight/obese) was screened for fungal colonization across multiple anatomical sites. Targeted sequencing of the Results: Fungal colonization was prevalent, with Conclusion: Our findings demonstrate that the diabetic population harbors a widespread, previously unrecognized deficiency in the Dectin-1/CARD9 signaling pathway. This shifts the clinical narrative of
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