Evidence map›Paper›PMID 42338508›Full record

ArticleBioactive materials2026

Growth plate cartilage-targeting nanoparticles for pharmacological treatment of hypochondroplasia.

Shang-Hui Ye, Lian-Jie Li, Yi-Jiao Wang, Cheng-Run Yuan, Jie Han, Dan He, Lin Che, Xiao-Hui Chen, Rong Shen, Jian Yang and 5 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Bioactive materials, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Shang-Hui YeThe First Affiliated Hospital of Xiamen University-ICMRS Collaborating Center for Skeletal Stem Cells, Faculty of Medicine and Life Sciences, School of Medicine, Xiamen University, Xiamen, 361102, China.
Lian-Jie LiThe First Affiliated Hospital of Xiamen University-ICMRS Collaborating Center for Skeletal Stem Cells, Faculty of Medicine and Life Sciences, School of Medicine, Xiamen University, Xiamen, 361102, China.
Yi-Jiao WangDepartment of Child Health, Department of Pediatrics, Women and Children's Hospital, School of Medicine, Xiamen University, Xiamen, 361102, China.
Cheng-Run YuanDepartment of Child Health, Department of Pediatrics, Women and Children's Hospital, School of Medicine, Xiamen University, Xiamen, 361102, China.
Jie HanThe First Affiliated Hospital of Xiamen University-ICMRS Collaborating Center for Skeletal Stem Cells, Faculty of Medicine and Life Sciences, School of Medicine, Xiamen University, Xiamen, 361102, China.
Dan HeDepartment of Child Health, Department of Pediatrics, Women and Children's Hospital, School of Medicine, Xiamen University, Xiamen, 361102, China.
Lin CheState Key Laboratory of Oncology in South China, Sun Yat-sen University Cancer Center, Guangzhou, 510060, China.
Xiao-Hui ChenThe First Affiliated Hospital of Xiamen University-ICMRS Collaborating Center for Skeletal Stem Cells, Faculty of Medicine and Life Sciences, School of Medicine, Xiamen University, Xiamen, 361102, China.
Rong ShenFujian Provincial Key Laboratory of Organ and Tissue Regeneration, School of Medicine, Xiamen University, Xiamen, 361102, China.
Jian YangDepartment of Materials Science and Engineering, Westlake University, Hangzhou, 310030, China.
Matthew B GreenblattDepartment of Pathology and Laboratory Medicine, Weill Cornell Medicine, New York, NY, 10065, USA.
Xian-Xian YangDepartment of Plastic and Reconstructive Surgery, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200011, China.
Jian-Min HuangDepartment of Orthopedics, Chenggong Hospital (73rd) affiliated to Xiamen University, Xiamen, 361000, China.
Jing ChenDepartment of Child Health, Department of Pediatrics, Women and Children's Hospital, School of Medicine, Xiamen University, Xiamen, 361102, China.
Ren XuThe First Affiliated Hospital of Xiamen University-ICMRS Collaborating Center for Skeletal Stem Cells, Faculty of Medicine and Life Sciences, School of Medicine, Xiamen University, Xiamen, 361102, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Hypochondroplasia (HCH) is a systemic cartilage disorder caused by gain-of-function mutations in

Indexed as

Chondrocyte membranesDrug deliveryGrowth plate cartilageHedgehog signaling pathwayHypochondroplasia

Identifiers

PMID42338508
PMCPMC13284457

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.