Evidence map›Paper›PMID 42338506›Full record

ArticleBioactive materials2026

Immunomodulatory cytoskeleton of bionic periosteum affects mitochondrial dynamics to promote osteogenesis.

Tianyu Zhou, Zhengxia Ni, Yiyang Huang, Ziyan Huang, Qiangqiang Guo, Jie Wu, Hongyi Zhu, Xinzhao Jiang, Liang Zhou, Wei Wang and 4 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Bioactive materials, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Tianyu ZhouDepartment of Orthopaedics, Xiangcheng People's Hospital, 1060 Huayuan Road, Suzhou, Jiangsu, 215006, PR China.
Zhengxia NiDepartment of Orthopaedics, The First Affiliated Hospital of Suzhou University, Institute of Orthopaedic Research, Suzhou University, No. 188 Shizi Street, Suzhou, Jiangsu, 215006, PR China.
Yiyang HuangDepartment of Orthopaedics, The First Affiliated Hospital of Suzhou University, Institute of Orthopaedic Research, Suzhou University, No. 188 Shizi Street, Suzhou, Jiangsu, 215006, PR China.
Ziyan HuangDepartment of Orthopaedics, The First Affiliated Hospital of Suzhou University, Institute of Orthopaedic Research, Suzhou University, No. 188 Shizi Street, Suzhou, Jiangsu, 215006, PR China.
Qiangqiang GuoDepartment of Orthopaedics, The First Affiliated Hospital of Suzhou University, Institute of Orthopaedic Research, Suzhou University, No. 188 Shizi Street, Suzhou, Jiangsu, 215006, PR China.
Jie WuDepartment of Orthopaedics, The First Affiliated Hospital of Suzhou University, Institute of Orthopaedic Research, Suzhou University, No. 188 Shizi Street, Suzhou, Jiangsu, 215006, PR China.
Hongyi ZhuDepartment of Orthopaedics, The First Affiliated Hospital of Suzhou University, Institute of Orthopaedic Research, Suzhou University, No. 188 Shizi Street, Suzhou, Jiangsu, 215006, PR China.
Xinzhao JiangDepartment of Orthopaedics, The First Affiliated Hospital of Suzhou University, Institute of Orthopaedic Research, Suzhou University, No. 188 Shizi Street, Suzhou, Jiangsu, 215006, PR China.
Liang ZhouDepartment of Orthopaedics, The First Affiliated Hospital of Suzhou University, Institute of Orthopaedic Research, Suzhou University, No. 188 Shizi Street, Suzhou, Jiangsu, 215006, PR China.
Wei WangDepartment of Orthopaedics, The First Affiliated Hospital of Suzhou University, Institute of Orthopaedic Research, Suzhou University, No. 188 Shizi Street, Suzhou, Jiangsu, 215006, PR China.
Kun XiDepartment of Orthopaedics, The First Affiliated Hospital of Suzhou University, Institute of Orthopaedic Research, Suzhou University, No. 188 Shizi Street, Suzhou, Jiangsu, 215006, PR China.
Yong GuDepartment of Orthopaedics, The First Affiliated Hospital of Suzhou University, Institute of Orthopaedic Research, Suzhou University, No. 188 Shizi Street, Suzhou, Jiangsu, 215006, PR China.
Wenguo CuiDepartment of Orthopaedics, Shanghai Key Laboratory for Prevention and Treatment of Bone and Joint Diseases, Shanghai Institute of Traumatology and Orthopaedics, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, 197 Ruijin 2nd Road, Shanghai, 200025, PR China.
Liang ChenDepartment of Orthopaedics, The First Affiliated Hospital of Suzhou University, Institute of Orthopaedic Research, Suzhou University, No. 188 Shizi Street, Suzhou, Jiangsu, 215006, PR China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Purpose: Periosteum is a key regulatory hub in the immune microenvironment of bone repair and the mitochondrial dynamics of bone marrow mesenchymal stem cells (BMSCs) directly determine the osteogenic efficiency; therefore, how to promote bone healing through the immunomodulation of mitochondrial dynamics is a key challenge. Methods: Inspired by the natural periosteum, we designed a bionic periosteum that integrates topology and controlled Semaphorin 3 A (Sema3A) release. Hyaluronic acid-coated Sema3A granular microsols spontaneously formed a nucleus-sheath structure under a high-voltage electric field to facilitate efficient drug loading. Results: The periosteum controlled Sema3A release and oriented topography, which drived macrophage M2 polarization via the PI3K/Akt/mTOR pathway, reconstructed the BMSC skeleton via the ROCK2 pathway, and synergistically promoted bone formation by driving mitochondrial fusion through material-appropriate stiffness. In vivo experiments further demonstrated that this biomimetic periosteum efficiently repaired bone defects by activating the immune microenvironment to remodel the BMSC skeleton and modulating mitochondrial dynamics, an endogenous repair cascade. Conclusion: This immunomodulatory drug delivery strategy utilizing bionic periosteum offers a novel approach for regenerative medicine to regulate immune-osteogenic crosstalk, which is promising for potential applications.

Indexed as

Biomimetic periosteumBone immunityCytoskeletonMacrophage polarizationMitochondrial dynamicsOsteogenesis

Identifiers

PMID42338506
PMCPMC13284458

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.