ArticleFuture science OA2026
Serum trace metals across environmental-pressure strata in Campania, Italy (SPES): a population-based cross-sectional biomonitoring study.
Article in Future science OA, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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Who cites it
3 citing papers in PubMed.
- Article
- Serum Trace Elements and Self-Reported Physician-Diagnosed Tumor History: A Secondary Cross-Sectional Analysis of the Exposure Study on Susceptible People (SPES).Medicina (Kaunas, Lithuania) · 2026Article
- Food-Source Patterns and Serum Trace-Metal Biomarkers in the SPES Population Biomonitoring Study, Campania, Italy.Journal of xenobiotics · 2026Article
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
BACKGROUND AND
objectivesWe characterized fine-scale geographic variation in serum trace metals across Campania (southern Italy). MATERIALS AND
methodsIn 2016-2017, the SPES programme sampled residents aged 20-49 years from municipal registries across Campania. Municipalities were stratified using an environmental-pressure index into three broad impact strata: high-impact, medium-impact and low-impact. For higher spatial resolution, municipalities were also grouped into 21 predefined municipal clusters. We measured 20 serum trace metals by ICP-MS and estimated age- and sex-adjusted geometric mean ratios (GMRs) comparing each stratum or cluster with the study-wide geometric mean.
resultsOf 4205 enrolled participants, 4188 were included. Medium-impact areas showed higher mercury (GMR 1.87, 95% CI 1.73-2.02) and antimony (1.95, 1.71-2.23) relative to the cohort average. At the municipal-cluster scale, the Irno Valley clusters around the Fonderie Pisano foundry (Baronissi-Pellezzano and Salerno) had about six-fold higher mercury (GMR 5.71 and 6.10) and about three-fold higher antimony (3.45 and 2.93), whereas the Valle del Sabato cluster showed about ten-fold higher antimony (GMR 10.5) and about seven-fold higher nickel (7.16) and cadmium (7.67).
conclusionsOverall serum metal concentrations were broadly comparable with European general-population ranges, but pronounced small-area heterogeneity indicates localized hotspots that provincial or regional averages can obscure.
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