ArticleAnnals of medicine2026
Lactate, mean platelet volume, and nSOFA as combined predictors of perforated necrotizing enterocolitis and mortality in preterm infants: a retrospective cohort study.
Article in Annals of medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundPerforated necrotizing enterocolitis (PNEC) is a lethal complication in preterm infants with high mortality, but timely identification and prognostic stratification remain clinically challenging.
methodsThis retrospective cohort study analyzed 110 preterm infants with surgical NEC admitted between 2023-2025, stratified into non-intestinal perforation (NIP group,
resultsCompared with the NIP group, the PNEC group had significantly higher lactate (6.0 vs. 3.9 mmol/L), mean platelet volume (MPV, 12.20 vs. 10.79 fL), neonatal Sequential Organ Failure Assessment (nSOFA, 5.0 vs. 2.0), and mortality (27.3% vs. 10.9%) (all
conclusionsThe combination of lactate, MPV, and nSOFA exhibits synergistic predictive value for PNEC and its associated mortality. Lactate and MPV identify early perforation risk, while nSOFA stratifies mortality risk. This combination provides clinical utility for the early intervention of high-risk neonates with NEC.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.