Evidence map›Paper›PMID 42338159›Full record

ArticleAnnals of clinical and translational neurology2026

Clinical and Modifiable Factors Associated With Disability and Relapse in MOGAD: A Multicentre Cohort Study.

Yingtao Wang, Shaoxin Tao, Qiujia Wang, Xiaoyu Xu, Hui Yao, Zheng Liu, Dawei Li, Zhandong Qiu, Jinming Han, Jiangwei Xia and 14 more

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Article in Annals of clinical and translational neurology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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5 · Who and what money

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24 authors.

Yingtao WangDepartment of Neurology, Xuanwu Hospital Capital Medical University, National Center for Neurological Disorders, Beijing, China.ORCID https://orcid.org/0000-0002-0249-648X
Shaoxin TaoDepartment of Neurology, Xuanwu Hospital Capital Medical University, National Center for Neurological Disorders, Beijing, China.
Qiujia WangDepartment of Neurology, Xuanwu Hospital Capital Medical University, National Center for Neurological Disorders, Beijing, China.
Xiaoyu XuDepartment of Neurology, Xuanwu Hospital Capital Medical University, National Center for Neurological Disorders, Beijing, China.
Hui YaoDepartment of Neurology, Xuanwu Hospital Capital Medical University, National Center for Neurological Disorders, Beijing, China.
Zheng LiuDepartment of Neurology, Xuanwu Hospital Capital Medical University, National Center for Neurological Disorders, Beijing, China.ORCID https://orcid.org/0000-0002-6092-6652
Dawei LiDepartment of Neurology, Xuanwu Hospital Capital Medical University, National Center for Neurological Disorders, Beijing, China.ORCID https://orcid.org/0000-0003-3696-658X
Zhandong QiuDepartment of Neurology, Xuanwu Hospital Capital Medical University, National Center for Neurological Disorders, Beijing, China.
Jinming HanDepartment of Neurology, Xuanwu Hospital Capital Medical University, National Center for Neurological Disorders, Beijing, China.
Jiangwei XiaDepartment of Neurology, Xuanwu Hospital Capital Medical University, National Center for Neurological Disorders, Beijing, China.
Qi WangDepartment of Neurology, Xuanwu Hospital Capital Medical University, National Center for Neurological Disorders, Beijing, China.
Jun SunDepartment of Neurology, Xuanwu Hospital Capital Medical University, National Center for Neurological Disorders, Beijing, China.
Kai ShaoDepartment of Neurology, Xuanwu Hospital Capital Medical University, National Center for Neurological Disorders, Beijing, China.
Jiao LiDepartment of Neurology, Xuanwu Hospital Capital Medical University, National Center for Neurological Disorders, Beijing, China.
Shishuang RuanDepartment of Neurology, Xuanwu Hospital Capital Medical University, National Center for Neurological Disorders, Beijing, China.
Yi ZhongDepartment of Neurology, Changde Hospital, Xiangya School of Medicine, Central South University (The First People's Hospital of Changde City), Changde, Hunan, China.
Jun GuoDepartment of Neurology, Tangdu Hospital, Fourth Military Medical University, Xi'an, Shaanxi, China.ORCID https://orcid.org/0000-0001-8053-881X
Shougang GuoDepartment of Neurology, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, Shandong, China.ORCID https://orcid.org/0000-0003-0748-6990
Yue HuangDepartment of Neurology, Henan Provincial People's Hospital, Zhengzhou, Henan, China.
Guoliang ChaiDepartment of Neurology, Xuanwu Hospital Capital Medical University, National Center for Neurological Disorders, Beijing, China.
Tao JinNeuroscience Center, Department of Neurology, The First Hospital of Jilin University, Changchun, Jilin, China.
Hongyu ZhouDepartment of Neurology, West China Hospital, Sichuan University, Chengdu, Sichuan, China.
Junwei HaoDepartment of Neurology, Xuanwu Hospital Capital Medical University, National Center for Neurological Disorders, Beijing, China.ORCID https://orcid.org/0000-0002-3075-5434
Yinan ZhaoDepartment of Neurology, Xuanwu Hospital Capital Medical University, National Center for Neurological Disorders, Beijing, China.

Funding

Beijing Hospital Authority 'Dengfeng' Talent Training Plan DFL20220701Beijing Research Ward Excellence Program BRWEP2024W022010101Chinese Institutes for Medical Research, Beijing CX23YZ15National Natural Science Foundation of China 82571539Pilot Project for Public Welfare Development and Reform of Beijing-affiliated Medical Research Institutes JYY2023-7Project for Innovation and Development of Beijing Municipal Geriatric Medical Research Center 11000023T000002041657Xuanwu Hospital Talent Convergence Program HZ2025PYDTR003Young Beijing Scholars Program 020
6 · The paper itself

Abstract

backgroundFactors associated with relapse course and disability in myelin oligodendrocyte glycoprotein antibody-associated disease (MOGAD) remain incompletely understood.

objectivesTo identify clinical and modifiable factors associated with relapse and disability in MOGAD.

methodsIn this ambispective multicentre cohort study using data from the Chinese Neuroimmunological Diseases (NIDBase) cohort (21 Chinese centres; January 2020-December 2024), 173 MOGAD patients with ≥ 12-month follow-up were analysed. Time to first relapse and time to disability, defined as Expanded Disability Status Scale (EDSS) score ≥ 2 confirmed outside acute relapse periods, were analysed using Cox regression. Nonlinear associations were assessed using restricted cubic splines.

resultsOlder age at onset and smoking history were associated with increased disability risk. Smoking was also associated with relapse risk, although its association was attenuated and no longer statistically significant after adjustment. BMI showed nonlinear associations with both relapse and disability outcomes.

conclusionsIn MOGAD, older age at onset, smoking, and BMI may influence prognosis. These findings support further investigation of modifiable lifestyle and metabolic factors in prognostic stratification.

Indexed as

cohort studymodifiable risk factorsMOGADprognosis

Identifiers

PMID42338159
PMCPMC13394838

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