Evidence map›Paper›PMID 42338095›Full record

ArticleJournal of veterinary pharmacology and therapeutics2026

Pharmacokinetics of Orally Administered Clonidine in Dogs.

Kevin Pflaum, Julia Albright, Sherry Cox, Joe Smith

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of veterinary pharmacology and therapeutics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Kevin PflaumSmall Animal Clinical Sciences, College of Veterinary Medicine, University of Tennessee, Knoxville, Tennessee, USA.ORCID https://orcid.org/0000-0002-7301-7917
Julia AlbrightSmall Animal Clinical Sciences, College of Veterinary Medicine, University of Tennessee, Knoxville, Tennessee, USA.ORCID https://orcid.org/0000-0003-3532-3806
Sherry CoxBiomedical and Diagnostic Sciences, College of Veterinary Medicine, University of Tennessee, Knoxville, Tennessee, USA.ORCID https://orcid.org/0000-0002-5184-900X
Joe SmithLarge Animal Clinical Sciences, College of Veterinary Medicine, University of Tennessee, Knoxville, Tennessee, USA.ORCID https://orcid.org/0000-0002-4288-2262

Funding

The University of Tennessee College of Veterinary Medicine Companion Animal Fund
6 · The paper itself

Abstract

Clonidine is an α-2 agonist shown to be both well tolerated and useful in the treatment of canine fear-based disorders, although it is perceived to have a short duration of action. Clonidine is available in regular release and extended-release formulations, but canine pharmacokinetic (PK) and pharmacodynamic (PD) data on any clonidine formulation are lacking. The aim of this study was to establish PK and PD parameters of regular release (RR) clonidine in dogs. Clonidine RR (n = 6) was orally administered at 0.05 mg/kg to laboratory beagles. Clonidine RR showed a maximum concentration (C

Indexed as

Adrenergic alpha-2 Receptor AgonistsClonidineAdministration, OralAnimalsArea Under CurveDogsFemaleHalf-LifeHeart RateMaleAdrenergic alpha-2 Receptor AgonistsClonidineclonidinedogfearpharmacodynamicspharmacokinetics

Identifiers

PMID42338095
PMCPMC13552510

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.