Evidence map›Paper›PMID 42338090›Full record

ReviewJournal of applied clinical medical physics2026

Conditional sparing in FLASH radiotherapy: Conformal dosimetry and ALARA remain essential.

Chih-Chiang Chang, Yangguang Ma, Minglei Kang, Bhudatt Paliwal, Zachary Morris, Benjamin Durkee, Chingyun Cheng

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Journal of applied clinical medical physics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Chih-Chiang ChangDepartment of Radiation Oncology, Mayo Clinic Arizona, Phoenix, Arizona, USA.
Yangguang MaDepartment of Radiation Oncology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, China.
Minglei KangDepartment of Radiation Medicine, University of Wisconsin-Madison, Madison, Wisconsin, USA.
Bhudatt PaliwalDepartment of Radiation Medicine, University of Wisconsin-Madison, Madison, Wisconsin, USA.
Zachary MorrisDepartment of Radiation Medicine, University of Wisconsin-Madison, Madison, Wisconsin, USA.
Benjamin DurkeeDepartment of Radiation Medicine, University of Wisconsin-Madison, Madison, Wisconsin, USA.
Chingyun ChengDepartment of Radiation Medicine, University of Wisconsin-Madison, Madison, Wisconsin, USA.ORCID https://orcid.org/0009-0005-3533-8153

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

FLASH radiotherapy shows promise in reducing normal tissue toxicity while maintaining tumor control. However, preclinical and early clinical evidence reveal biological and technical uncertainties. We review preclinical and veterinary studies, highlight unexpected toxicities, and argue that the fundamental principles of precision and safety in radiotherapy-particularly conformal treatment and ALARA-remain crucial.

Indexed as

NeoplasmsOrgans at RiskOrgan Sparing TreatmentsRadiotherapy, ConformalRadiotherapy Planning, Computer-AssistedAnimalsHumansRadiometryRadiotherapy DosageALARAdosimetryFLASH radiotherapynormal tissue sparingproton therapytoxicitytreatment planningultrahigh dose rate

Identifiers

PMID42338090
PMCPMC13291216

What OpenQuestion holds

Textmetadata
LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.