Evidence map›Paper›PMID 42338074›Full record

ArticleBioMed research international2026

Design and Synthesis of 2-En-4-Ynedioate Compounds as Novel and Potential Antifungal Agents.

Mohadese Mohammadi, Soroush Sardari, Parisa Azerang, Parviz Rashidi Ranjbar

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BioMed research international, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Mohadese MohammadiDepartment of Chemistry, College of Science, University of Tehran, Tehran, Iran, ut.ac.ir.ORCID https://orcid.org/0000-0002-8511-0289
Soroush SardariDrug Design and Bioinformatics Unit, Medical Biotechnology Department, Biotechnology Research Center, Pasteur Institute of Iran, Tehran, Iran, pasteur.ac.ir.ORCID https://orcid.org/0000-0001-5984-0336
Parisa AzerangClinical Research Department, Pasteur Institute of Iran, Tehran, Iran, pasteur.ac.ir.ORCID https://orcid.org/0000-0002-9851-2658
Parviz Rashidi RanjbarDepartment of Chemistry, College of Science, University of Tehran, Tehran, Iran, ut.ac.ir.ORCID https://orcid.org/0000-0001-8917-5330

Funding

Pasteur Institute of Iran 1169
6 · The paper itself

Abstract

In this investigation, we focused on generating innovative antifungal agents inspired by terbinafine, a prominent allylamine that inhibits squalene epoxidase and is a crucial enzyme in the biosynthesis of fungal ergosterol. Utilizing computational methods such as molecular docking and molecular dynamics (MD) simulations, we designed and synthesized a collection of enyne derivatives featuring aromatic side chains. The choice of these compounds was influenced by their anticipated interactions with squalene epoxidase, informed by comprehensive in silico assessments. The synthesized derivatives were analyzed using

Indexed as

Antifungal AgentsDrug DesignAspergillus nigerCandida albicansMicrobial Sensitivity TestsMolecular Docking SimulationMolecular Dynamics SimulationSaccharomyces cerevisiaeSqualene MonooxygenaseTerbinafineAntifungal AgentsSqualene MonooxygenaseTerbinafineantifungal drugsin silicosqualene epoxidasesynthesis

Identifiers

PMID42338074
PMCPMC13291183

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.