Evidence map›Paper›PMID 42338061›Full record

ArticleAngewandte Chemie (International ed. in English)2026

Photo-Triggered, Fast, and Fluorogenic Thiophene-Based Cycloalkynes for the Bioorthogonal Fluorescent Labeling of 1,3-Dipole-Tagged Molecules in No-Wash Conditions.

Jurgen Schulz, Zoeisha S Chinoy, Tarek Khalaf, Yukang Li, Pengchen Ma, Dennis Svatunek, Kendall N Houk, Frédéric Friscourt

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Angewandte Chemie (International ed. in English), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Jurgen SchulzInstitut Européen de Chimie et Biologie, Université De Bordeaux, Pessac, France.
Zoeisha S ChinoyInstitut Européen de Chimie et Biologie, Université De Bordeaux, Pessac, France.ORCID 0000-0003-4654-5711
Tarek KhalafInstitut Européen de Chimie et Biologie, Université De Bordeaux, Pessac, France.
Yukang LiSchool of Chemistry, Xi'an Jiaotong University, Xi'an, China.
Pengchen MaSchool of Chemistry, Xi'an Jiaotong University, Xi'an, China.ORCID 0000-0002-4110-4696
Dennis SvatunekDepartment of Chemistry and Biochemistry, University of California, Los Angeles, USA.ORCID 0000-0003-1101-2376
Kendall N HoukDepartment of Chemistry and Biochemistry, University of California, Los Angeles, USA.ORCID 0000-0002-8387-5261
Frédéric FriscourtInstitut Européen de Chimie et Biologie, Université De Bordeaux, Pessac, France.ORCID 0000-0002-0749-0861

Funding

ANR ANR-21-CE16-0021-02 to F.FANR ANR-21-EXES-0004 to F.FNational Science Foundation CHE-2153972
6 · The paper itself

Abstract

Bioorthogonal reactions have revolutionized our way of performing chemistry in a highly complex biological environment. In particular, strain-promoted 1,3-dipolar cycloadditions, employing cyclooctyne probes in conjunction with azido-reporters (strain-promoted alkyne-azide cycloaddition, SPAAC), have permitted the labeling and visualization of bio-macromolecules in vitro, in living cells, as well as in animals. However, SPAAC's slow kinetics (< 1 M

Indexed as

AlkynesFluorescent DyesThiophenesAzidesCycloaddition ReactionKineticsMolecular StructureAlkynesAzidesFluorescent DyesThiophenes1,3‐dipolar cycloadditionbioorthogonal reactionsclick chemistryfluorescence imagingfluorogenic probes

Identifiers

PMID42338061
PMCPMC13502660

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.