Evidence map›Paper›PMID 42337705›Full record

ArticleBMC cancer2026

Over-presentation of apolipoprotein E gene variants E3/E4 and cardiovascular disease risk factors among Ghanaian breast cancer patients.

Daniel Nii Martey Antonio, Max Annani-Akollor, Linda Ahenkorah Fondjo, Yvonne Anang-Quartey, Hubert Owusu, Benjamin Arko-Boham, Sheila Santa, Osbourne Quaye, Emmanuel Ayitey Tagoe

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Article in BMC cancer, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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5 · Who and what money

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9 authors.

Daniel Nii Martey Antonio *Department of Molecular Medicine, Kwame Nkrumah University of Science and Technology, Kumasi, Ghana.
Max Annani-Akollor *Department of Molecular Medicine, Kwame Nkrumah University of Science and Technology, Kumasi, Ghana.
Linda Ahenkorah FondjoDepartment of Molecular Medicine, Kwame Nkrumah University of Science and Technology, Kumasi, Ghana.
Yvonne Anang-QuarteyDepartment of Medical Laboratory Sciences, School of Biomedical and Allied Health Sciences, College of Health Sciences, University of Ghana, P.O. Box KB 143, Korle-Bu, Accra, Ghana.
Hubert OwusuDepartment of Molecular Medicine, Kwame Nkrumah University of Science and Technology, Kumasi, Ghana.
Benjamin Arko-BohamDepartment of Anatomy, College of Health Sciences, University of Ghana Medical School, University of Ghana, Accra, Ghana.
Sheila SantaDepartment of Medical Laboratory Sciences, School of Biomedical and Allied Health Sciences, College of Health Sciences, University of Ghana, P.O. Box KB 143, Korle-Bu, Accra, Ghana.
Osbourne QuayeDepartment of Biochemistry, Cell and Molecular Biology / West African Centre for Cell Biology of Infectious Pathogens, College of Basic and Applied Sciences, University of Ghana, Accra, Ghana.
Emmanuel Ayitey TagoeDepartment of Medical Laboratory Sciences, School of Biomedical and Allied Health Sciences, College of Health Sciences, University of Ghana, P.O. Box KB 143, Korle-Bu, Accra, Ghana. eatagoe@ug.edu.gh.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundApolipoprotein E (APO E), a member of the apolipoprotein family, plays a crucial role in lipid metabolism. The association between dyslipidaemia and breast cancer remains inconclusive, and the relationship between APO E gene variants and breast cancer is not well established. This study aimed to determine the distribution of APO E gene variants and assess dyslipidaemia as cardiovascular disease risk factor among Ghanaian breast cancer patients.

methodsA case-control approach was used, involving 140 participants comprising 70 breast cancer patients and 70 age-matched non-cancer individuals. Socio-demographic and clinicopathological data were collected using a structured questionnaire. Polymerase chain reaction-restriction fragment length polymorphism analysis was performed on the extracted DNA to determine APO E variants. Serum lipid profiles were assessed using an automated chemistry analyser, and serum lipids indices as cardiovascular diseases risk factors including atherogenic index of plasma were calculated. STATA version 19.0 was used for statistical analysis.

resultsThe APO E3/E4 variant was significantly associated with breast cancer (OR = 2.9; p < 0.001). Breast cancer patients showed elevated levels of triglycerides (TG), total cholesterol (TC), and low-density lipoprotein cholesterol (LDL-c), while high-density lipoprotein cholesterol (HDL-c) levels were lower, suggesting a higher risk of cardiovascular diseases among breast cancer patients compared to the control group (p < 0.001). Also, MDA levels were found to be significantly lower among breast cancer patients compared to the healthy control group (p < 0.01).

conclusionAPO E, E3/E4 variant was associated with breast cancer and may contribute to the increased cardiovascular disease risk among the breast cancer patients.

Indexed as

Apolipoprotein E3Apolipoprotein E4Apolipoproteins EBreast NeoplasmsCardiovascular DiseasesAdultAgedCase-Control StudiesDyslipidemiasFemaleGenetic Predisposition to DiseaseGhanaHeart Disease Risk FactorsHumansLipidsMiddle AgedApolipoprotein E3Apolipoprotein E4Apolipoproteins ELipidsApolipoprotein E variantsAtherogenic indexBreast cancerCardiovascular diseases risk factorsDyslipidaemia

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PMID42337705

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