Evidence map›Paper›PMID 42337659›Full record

ArticleJournal of nanobiotechnology2026

Cold exposure-induced loss of beneficial gut bacterial sEV is associated with the pathogenesis of bone loss through pyroptosis pathway.

Li-Min Lei, Xiao Lin, Feng Xu, Fu-Xing-Zi Li, Su-Kang Shan, Ming-Hui Zheng, Bei Guo, Ye-Chi Cao, Zhi-Ang Zhou, Si-Yang He and 11 more

Abstract read
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In one paragraph

Article in Journal of nanobiotechnology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

21 authors.

Li-Min LeiNational Clinical Research Center for Endocrine and Metabolic Diseases, Hunan Provincial Key Laboratory of Metabolic Bone Diseases, Department of Endocrinology and Metabolism, The Second Xiangya Hospital, Central South University, Changsha, China.
Xiao LinDepartment of Radiology, The Second Xiangya Hospital, Central South University, Changsha, China.
Feng XuNational Clinical Research Center for Endocrine and Metabolic Diseases, Hunan Provincial Key Laboratory of Metabolic Bone Diseases, Department of Endocrinology and Metabolism, The Second Xiangya Hospital, Central South University, Changsha, China.
Fu-Xing-Zi LiNational Clinical Research Center for Endocrine and Metabolic Diseases, Hunan Provincial Key Laboratory of Metabolic Bone Diseases, Department of Endocrinology and Metabolism, The Second Xiangya Hospital, Central South University, Changsha, China.
Su-Kang ShanNational Clinical Research Center for Endocrine and Metabolic Diseases, Hunan Provincial Key Laboratory of Metabolic Bone Diseases, Department of Endocrinology and Metabolism, The Second Xiangya Hospital, Central South University, Changsha, China.
Ming-Hui ZhengNational Clinical Research Center for Endocrine and Metabolic Diseases, Hunan Provincial Key Laboratory of Metabolic Bone Diseases, Department of Endocrinology and Metabolism, The Second Xiangya Hospital, Central South University, Changsha, China.
Bei GuoDepartment of Metabolism and Endocrinology, General Hospital of Northern Theater Command, Shenyang, 110016, Liaoning, China.
Ye-Chi CaoNational Clinical Research Center for Endocrine and Metabolic Diseases, Hunan Provincial Key Laboratory of Metabolic Bone Diseases, Department of Endocrinology and Metabolism, The Second Xiangya Hospital, Central South University, Changsha, China.
Zhi-Ang ZhouDepartment of Cardiovascular Surgery, the Second Xiangya Hospital, Central South University, Changsha, China.
Si-Yang HeNational Clinical Research Center for Endocrine and Metabolic Diseases, Hunan Provincial Key Laboratory of Metabolic Bone Diseases, Department of Endocrinology and Metabolism, The Second Xiangya Hospital, Central South University, Changsha, China.
Yan-Lin WuNational Clinical Research Center for Endocrine and Metabolic Diseases, Hunan Provincial Key Laboratory of Metabolic Bone Diseases, Department of Endocrinology and Metabolism, The Second Xiangya Hospital, Central South University, Changsha, China.
Xi ChenNational Clinical Research Center for Endocrine and Metabolic Diseases, Hunan Provincial Key Laboratory of Metabolic Bone Diseases, Department of Endocrinology and Metabolism, The Second Xiangya Hospital, Central South University, Changsha, China.
Fei ZhangNational Clinical Research Center for Endocrine and Metabolic Diseases, Hunan Provincial Key Laboratory of Metabolic Bone Diseases, Department of Endocrinology and Metabolism, The Second Xiangya Hospital, Central South University, Changsha, China.
Wen-Hui ZhangNational Clinical Research Center for Endocrine and Metabolic Diseases, Hunan Provincial Key Laboratory of Metabolic Bone Diseases, Department of Endocrinology and Metabolism, The Second Xiangya Hospital, Central South University, Changsha, China.
Jia-Qi ZhuNational Clinical Research Center for Endocrine and Metabolic Diseases, Hunan Provincial Key Laboratory of Metabolic Bone Diseases, Department of Endocrinology and Metabolism, The Second Xiangya Hospital, Central South University, Changsha, China.
Ya-Rong WangNational Clinical Research Center for Endocrine and Metabolic Diseases, Hunan Provincial Key Laboratory of Metabolic Bone Diseases, Department of Endocrinology and Metabolism, The Second Xiangya Hospital, Central South University, Changsha, China.
Qi-Rong DengNational Clinical Research Center for Endocrine and Metabolic Diseases, Hunan Provincial Key Laboratory of Metabolic Bone Diseases, Department of Endocrinology and Metabolism, The Second Xiangya Hospital, Central South University, Changsha, China.
Zi-Ping HeNational Clinical Research Center for Endocrine and Metabolic Diseases, Hunan Provincial Key Laboratory of Metabolic Bone Diseases, Department of Endocrinology and Metabolism, The Second Xiangya Hospital, Central South University, Changsha, China.
Feng WuDepartment of Pathology, The Second Xiangya Hospital, Central South University, Changsha, 410011, Hunan, China.
Ling-Qing YuanNational Clinical Research Center for Endocrine and Metabolic Diseases, Hunan Provincial Key Laboratory of Metabolic Bone Diseases, Department of Endocrinology and Metabolism, The Second Xiangya Hospital, Central South University, Changsha, China. allenylq@csu.edu.cn.ORCID http://orcid.org/0000-0001-8602-7113
Zhi-Hong LiDepartment of Orthopaedics, The Second Xiangya Hospital, Central South University, Changsha, 410011, Hunan, China. lizhihong@csu.edu.cn.

Funding

Fundamental Research Funds for the Central Universities of Central South University 2025ZZTS0147Fundamental Research Funds for the Central Universities of Central South University No.2025ZZTS0807Fundamental Research Funds for the Central Universities of Central South University No.2026ZZTS0107Key R&D Plan of Hunan Province 2020SK2078National Clinical Key Specialties Main Research Projects No. Z2023026National Key Research and Development Program of China No. 2023YFC2507600the National Natural Science Foundation of China No.82100494the National Natural Science Foundation of China No. 82200869the National Natural Science Foundation of China No.82470927the National Natural Science Foundation of China No. 82571030, 82370892the Natural Science Foundation of Hunan Province No. 2021JJ30036The Natural Science Foundation of Hunan Province No.2025JJ60687
6 · The paper itself

Abstract

Recent studies suggest that cold temperature (CT) exposure contributes to osteoporosis. While the gut microbiota (GM) is a key regulator of host physiology, CT conditions significantly alter its composition. In this study, we found that co-housing with room temperature (RT) mice, as well as colonization with RT-donor GM, conferred protection against CT-induced bone loss. Using 16 S rRNA gene sequencing, we demonstrated that the CT-triggered decline in intestinal Bifidobacterium pseudolongum (B. p) abundance was rescued by co-housing with RT mice. Furthermore, oral administration of B. p effectively alleviated CT-induced bone loss. Mechanistically, we identified that small extracellular vesicles derived from Bifidobacterium. pseudolongum (B. p-sEVs) were taken up by bone tissue, where they enhanced osteogenesis and suppressed pyroptosis in bone marrow stromal cells (BMSCs). Collectively, our findings suggest that the GM helps preserve bone mass via bacterial sEVs, and that the reduction of B. p and its derived sEVs drives CT-induced bone loss.

Indexed as

Cold TemperatureGastrointestinal MicrobiomeOsteoporosisPyroptosisAnimalsBifidobacteriumBone ResorptionMaleMiceMice, Inbred C57BLOsteogenesisBifidobacterium pseudolongumCold exposureGut microbiotaOsteoporosisPyroptosis

Identifiers

PMID42337659
PMCPMC13548517

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.