ArticleJournal of eating disorders2026
Aberrant large- and mesoscale network segregation and integration in bulimia nervosa.
Article in Journal of eating disorders, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
backgroundGrowing evidence indicates that bulimia nervosa (BN) is more likely driven by network-level dysfunctions rather than abnormalities in isolated brain regions. However, previous studies focusing on specific regions or connectivity features have led to a limited understanding of the complexity and integrality of network in BN. This study aimed to investigate large- and mesoscale network alterations in BN from the perspective of network segregation and integration.
methodsUsing resting-state functional magnetic resonance imaging data from 85 BN patients and 71 healthy controls (HCs) matched for age, sex, and education, we applied a graph-theoretic framework to analyze functional network architecture in BN. Specifically, we examined group differences in within- and between-system functional connectivity (FC) as well as system segregation at both the whole-brain and system levels. Associations between network measures and clinical features were further explored.
resultsCompared with HCs, BN patients exhibited whole-brain reduced within- and between-system FC accompanied by increased system segregation. At the system level, patients showed increased between-system FC of the default mode network (DMN), control network and ventral attention network, along with decreased DMN system segregation. The increased integration of DMN with other systems was associated with higher Beck Depression Inventory (BDI-21) scores in BN patients.
conclusionsThe neural mechanisms of BN involve an imbalance between network segregation and integration at both global and system levels, most pronounced within the DMN, whose alterations are associated with depression and disordered eating behavior. These findings may provide potential neural substrates for some core behavioral deficits in BN.
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