Evidence map›Paper›PMID 42337630›Full record

SynthesisMolecular neurodegeneration2026

A reappraisal of APOE genetic effects on Alzheimer's disease risk in the Japanese population: a meta-analysis.

Akinori Miyashita, Norikazu Hara, Ai Obinata, Tamao Tsukie, Mai Hasegawa, Takanobu Ishiguro, Kensaku Kasuga, Masataka Kikuchi, Tadafumi Hashimoto, Takahisa Kanekiyo and 1 more

Abstract readLetterMeta-Analysis
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Molecular neurodegeneration, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Akinori MiyashitaDepartment of Molecular Genetics, Brain Research Institute, Niigata University, 1-757 Asahimachi, Chuo-ku, Niigata, 951-8585, Japan. miyashi2020@bri.niigata-u.ac.jp.
Norikazu HaraDepartment of Molecular Genetics, Brain Research Institute, Niigata University, 1-757 Asahimachi, Chuo-ku, Niigata, 951-8585, Japan.
Ai ObinataDepartment of Molecular Genetics, Brain Research Institute, Niigata University, 1-757 Asahimachi, Chuo-ku, Niigata, 951-8585, Japan.
Tamao TsukieDepartment of Molecular Genetics, Brain Research Institute, Niigata University, 1-757 Asahimachi, Chuo-ku, Niigata, 951-8585, Japan.
Mai HasegawaDepartment of Molecular Genetics, Brain Research Institute, Niigata University, 1-757 Asahimachi, Chuo-ku, Niigata, 951-8585, Japan.
Takanobu IshiguroDepartment of Neurology, Brain Research Institute, Niigata University, Niigata, Japan.
Kensaku KasugaDepartment of Molecular Genetics, Brain Research Institute, Niigata University, 1-757 Asahimachi, Chuo-ku, Niigata, 951-8585, Japan.
Masataka KikuchiDepartment of Molecular Genetics, Brain Research Institute, Niigata University, 1-757 Asahimachi, Chuo-ku, Niigata, 951-8585, Japan.
Tadafumi HashimotoDepartment of Degenerative Neurological Diseases, National Institute of Neuroscience, National Center of Neurology and Psychiatry, Kodaira, Japan.
Takahisa KanekiyoDepartment of Neuroscience, Mayo Clinic, Jacksonville, FL, USA.
Takeshi IkeuchiDepartment of Molecular Genetics, Brain Research Institute, Niigata University, 1-757 Asahimachi, Chuo-ku, Niigata, 951-8585, Japan. ikeuchi@bri.niigata-u.ac.jp.

Funding

AMED JP26dk0207082 (TI)JSPS Grant-in-Aid for Scientific Research (KAKENHI) (B) 21H03537 (AM)JSPS Grant-in-Aid for Scientific Research (KAKENHI) (C) 21K07271 (AM)
6 · The paper itself

Abstract

Our meta-analysis demonstrates that the risk effect of APOE-e4*4 relative to APOE-e3*3 for Alzheimer's disease in the Japanese population is approximately 12-15-fold, comparable to that reported in Caucasian populations, rather than greater than 20-fold as previously reported.

Indexed as

Alzheimer DiseaseApolipoproteins EEast Asian PeopleGenetic Predisposition to DiseaseHumansJapanRisk FactorsApolipoproteins E

Identifiers

PMID42337630
PMCPMC13292320

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.