Evidence map›Paper›PMID 42337593›Full record

ArticleActa neuropathologica communications2026

Localized amyloid-β oligomers in the lateral entorhinal cortex drives olfactory dysfunction through aberrant neuronal and network activity.

Ting Pan, Jiaxing Fang, Xiao Wang, Yimeng Chen, Shan Li, Gaoxue Qiu, Changcheng Sun, Chao Liu, Anan Li, Fengjiao Chen

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Acta neuropathologica communications, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Ting Pan *Jiangsu Key Laboratory of Brain Disease and Bioinformation, Research Center for Biochemistry and Molecular Biology, Xuzhou Medical University, 209th Tongshan Road, Xuzhou, 221004, Jiangsu, China.
Jiaxing Fang *Jiangsu Key Laboratory of Brain Disease and Bioinformation, Research Center for Biochemistry and Molecular Biology, Xuzhou Medical University, 209th Tongshan Road, Xuzhou, 221004, Jiangsu, China.
Xiao WangJiangsu Key Laboratory of Brain Disease and Bioinformation, Research Center for Biochemistry and Molecular Biology, Xuzhou Medical University, 209th Tongshan Road, Xuzhou, 221004, Jiangsu, China.
Yimeng ChenJiangsu Key Laboratory of Brain Disease and Bioinformation, Research Center for Biochemistry and Molecular Biology, Xuzhou Medical University, 209th Tongshan Road, Xuzhou, 221004, Jiangsu, China.
Shan LiJiangsu Key Laboratory of Brain Disease and Bioinformation, Research Center for Biochemistry and Molecular Biology, Xuzhou Medical University, 209th Tongshan Road, Xuzhou, 221004, Jiangsu, China.
Gaoxue QiuJiangsu Key Laboratory of Brain Disease and Bioinformation, Research Center for Biochemistry and Molecular Biology, Xuzhou Medical University, 209th Tongshan Road, Xuzhou, 221004, Jiangsu, China.
Changcheng SunJiangsu Key Laboratory of Brain Disease and Bioinformation, Research Center for Biochemistry and Molecular Biology, Xuzhou Medical University, 209th Tongshan Road, Xuzhou, 221004, Jiangsu, China.
Chao LiuJiangsu Province Key Laboratory of Anesthesiology, Jiangsu Province Key Laboratory of Anesthesiology and Brain Science, NMPA Key Laboratory for Research and Evaluation of Narcotic and Psychotropic Drugs, School of Anesthesiology, Xuzhou Medical University, Xuzhou, China.
Anan LiJiangsu Key Laboratory of Brain Disease and Bioinformation, Research Center for Biochemistry and Molecular Biology, Xuzhou Medical University, 209th Tongshan Road, Xuzhou, 221004, Jiangsu, China. anan.li@xzhmu.edu.cn.
Fengjiao ChenJiangsu Key Laboratory of Brain Disease and Bioinformation, Research Center for Biochemistry and Molecular Biology, Xuzhou Medical University, 209th Tongshan Road, Xuzhou, 221004, Jiangsu, China. fengjiaochen@xzhmu.edu.cn.

Funding

Faculty Development Grant of Basic Medical Sciences, Xuzhou Medical University JC20250001Jiangsu Training Program of Innovation and Entrepreneurship for Undergraduates 202410313103YNational Natural Science Foundation of China 32100807National Natural Science Foundation of China 32271055 and 32471058
6 · The paper itself

Abstract

Olfactory dysfunction is one of the most common early features of Alzheimer's disease (AD), yet its underlying neural mechanisms remains unclear. The lateral entorhinal cortex (LEC), a central node in the olfactory network, is among the earliest regions affected by AD pathology. However, the direct evidence supporting a causal link between LEC dysfunction and olfactory disorders in early AD is limited. In the present study, we explored whether and how LEC dysfunction contributes to early AD olfactory dysfunction by injecting amyloid-β

Indexed as

Amyloid beta-PeptidesEntorhinal CortexNerve NetNeuronsOlfaction DisordersPeptide FragmentsAction PotentialsAnimalsDisease Models, AnimalMaleMiceMice, Inbred C57BLOdorantsAmyloid beta-Peptidesamyloid beta-protein (1-42)Peptide FragmentsAD‑related olfactory dysfunctionAmyloid-βLateral entorhinal cortexOlfactory

Identifiers

PMID42337593
PMCPMC13548545

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.