Evidence map›Paper›PMID 42337479›Full record

ReviewBMC pediatrics2026

A complex case of piperacillin-tazobactam resistant Elizabethkingia anophelis neonatal meningitis: the challenge of treatment and literature review.

Yixiang Wu, Sitian Ke, Lizhong Du, Zhongyue Li

Abstract readCase ReportsReview
PubMed Full text at PMC Publisher
In one paragraph

Review in BMC pediatrics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Yixiang WuDepartment of Pediatrics, the Fourth Affiliated Hospital of School of Medicine, and International School of Medicine, International Institutes of Medicine, Zhejiang University, Yiwu, Zhejiang, China.
Sitian KeDepartment of Pediatrics, the Fourth Affiliated Hospital of School of Medicine, and International School of Medicine, International Institutes of Medicine, Zhejiang University, Yiwu, Zhejiang, China.
Lizhong DuDepartment of Pediatrics, Children's Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, China.
Zhongyue LiDepartment of Pediatrics, the Fourth Affiliated Hospital of School of Medicine, and International School of Medicine, International Institutes of Medicine, Zhejiang University, Yiwu, Zhejiang, China. 6195006@zju.edu.cn.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundElizabethkingia anophelis is an emerging multidrug-resistant pathogen associated with severe neonatal infections and high mortality. Due to its intrinsic resistance to multiple antibiotics, including β-lactams, optimal antimicrobial therapy remains challenging. We report a rare case of neonatal meningitis complicated by brain abscess caused by piperacillin-tazobactam-resistant Elizabethkingia anophelis. CASE PRESENTATION: A full-term neonate presented with fever and poor responsiveness on day 15 after birth. Initial empirical antibiotic therapy was ineffective. Blood culture confirmed Elizabethkingia anophelis with resistance to piperacillin-tazobactam. Based on antimicrobial susceptibility testing, the treatment regimen was adjusted to levofloxacin combined with vancomycin. The patient showed marked clinical improvement, with normalization of temperature, negative blood cultures, and gradual resolution of the brain abscess. No significant adverse effects were observed during treatment.

conclusionThis case highlights the challenge of individualized antimicrobial selection in piperacillin-tazobactam-resistant neonatal Elizabethkingia meningitis. Early pathogen identification and timely optimization of antimicrobial therapy, including the judicious use of fluoroquinolones, may be critical for improving clinical outcomes.

Indexed as

Anti-Bacterial AgentsBrain AbscessDrug Resistance, Multiple, BacterialFlavobacteriaceaeFlavobacteriaceae InfectionsMeningitis, BacterialPenicillanic AcidHumansInfant, NewbornLevofloxacinMalePiperacillinPiperacillin, Tazobactam Drug CombinationVancomycinAnti-Bacterial AgentsLevofloxacinPenicillanic AcidPiperacillinPiperacillin, Tazobactam Drug CombinationVancomycinAntimicrobial resistanceBrain abscessElizabethkingia anophelisMeningitisNneonate

Identifiers

PMID42337479
PMCPMC13551919

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.