Evidence map›Paper›PMID 42337475›Full record

ArticleBMC surgery2026

Kidney transplantation - colour doppler and contrast-enhanced ultrasound in the early postoperative assessment of delayed graft function: retrospective results and pilot prospective findings.

Matteo Zanchetta, Marika Morabito, Marta Ripamonti, Linda Liepa, Valentina Iori, Gian Luigi Adani, Andrea Coppola, Federico Fontana, Davide Inversini, K. T.-CEUS Workgroup and 2 more

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Article in BMC surgery, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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4 · The record

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5 · Who and what money

Authors and funding

12 authors.

Matteo ZanchettaDepartment of Medicine Surgery and Neuroscience, Surgical Oncology Unit, University of Siena, Siena, Italy.
Marika MorabitoGeneral, Emergency and Transplant Surgery Department, ASST-Sette Laghi, Varese, 21100, Italy.
Marta RipamontiGeneral, Emergency and Transplant Surgery Department, ASST-Sette Laghi, Varese, 21100, Italy.
Linda LiepaGeneral, Emergency and Transplant Surgery Department, ASST-Sette Laghi, Varese, 21100, Italy.
Valentina IoriGeneral, Emergency and Transplant Surgery Department, ASST-Sette Laghi, Varese, 21100, Italy.
Gian Luigi AdaniDepartment of Medicine Surgery and Neuroscience, Kidney Transplant Unit, University of Siena, Siena, Italy.
Andrea CoppolaDiagnostic and Interventional Radiology Unit, Circolo Hospital, ASST Sette Laghi, Varese, 21100, Italy.
Federico FontanaDiagnostic and Interventional Radiology Unit, Circolo Hospital, ASST Sette Laghi, Varese, 21100, Italy.
Davide InversiniGeneral, Emergency and Transplant Surgery Department, ASST-Sette Laghi, Varese, 21100, Italy.
K. T.-CEUS Workgroup
Giulio CarcanoGeneral, Emergency and Transplant Surgery Department, ASST-Sette Laghi, Varese, 21100, Italy.
Giuseppe IettoGeneral, Emergency and Transplant Surgery Department, ASST-Sette Laghi, Varese, 21100, Italy. giuseppe.ietto@asst-settelaghi.it.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionDelayed graft function (DGF) remains a relevant early complication after kidney transplantation (KT), and reliable non-invasive imaging markers may improve postoperative graft assessment. MATERIALS AND

methodsWe retrospectively evaluated 381 KT recipients who underwent colour Doppler (CD) ultrasound (US) on postoperative day (POD) 1 and before discharge between January 2013 and February 2022. Resistive index (RI) measurements were analyzed in relation to DGF, defined as the need for at least one dialysis session within the first postoperative week. A prospective pilot subgroup of 25 recipients transplanted between February 2021 and February 2022 also underwent contrast-enhanced US (CEUS) between POD 1 and 3, with analysis of wash-in slope (WIS), time to peak (TTP), peak intensity (PI), and area under the curve (AUC).

resultsIn the retrospective cohort, 71 (18.6%) developed DGF. Higher RI values on POD 1 and before discharge were significantly associated with DGF. In the CEUS pilot subgroup, 7 patients (28.0%) developed DGF. Among CEUS-derived parameters, AUC was significantly associated with DGF, with lower values in patients who developed DGF and a valuable ROC AUC of 0.794.

conclusionsThese findings support a role for early postoperative CD in graft function assessment and suggest that CEUS-derived AUC may provide valuable complementary information in the early evaluation of grafts for DGF. However, the CEUS results are exploratory and require validation in larger prospective studies.

Indexed as

Delayed Graft FunctionKidney TransplantationUltrasonography, Doppler, ColorAdultContrast MediaFemaleHumansMaleMiddle AgedPilot ProjectsPostoperative PeriodProspective StudiesRetrospective StudiesContrast MediaCEUSContrast-enhanced ultrasoundDelayed graft functionDGFECDEchocolour dopplerKidney transplantKidney transplantationUltrasound

Identifiers

PMID42337475
PMCPMC13543518

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