SynthesisBMC surgery2026
Endoscopic sinus surgery combined with nasal corticosteroids and surgery alone for chronic rhinosinusitis with nasal polyps: a meta-analysis.
Synthesis in BMC surgery, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Authors and funding
2 authors.
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Abstract
objectiveThe purpose of this meta-analysis was to assess whether the outcomes of endoscopic sinus surgery in chronic rhinosinusitis with nasal polyps could be improved by adjunctive corticosteroid therapy.
methodsThis meta-analysis was conducted in accordance with the PRISMA statement. We systematically searched PubMed, Web of Science, and CNKI for clinical studies comparing ESS combined with corticosteroid therapy and ESS alone in patients with CRSwNP.
resultsEight clinical studies with an aggregate of 776 patients were included. Meta-analysis revealed: (1) A lower rate of polyp recurrence in the ESS plus corticosteroid therapy group (OR = 0.57, 95% CI: 0.33-0.97, P = 0.04); (2) Better sinonasal quality of life (SNOT-22: SMD = - 1.09, 95% CI: - 1.30 to - 0.89, P < 0.00001); (3) Decrease symptom score (VAS: MD = - 3.80, 95% CI: - 4.53 to - 3.07, P < 0.00001); (4) Better endoscopic outcome (Lund-Kennedy: SMD = - 2.05, 95% CI: - 2.27 to - 1.83, P < 0.00001). Heterogeneity was low (I² = 0%-4%), and funnel plots were generated exploratorily because of the limited number of studies.
conclusionESS combined with adjunctive corticosteroid therapy was associated with lower recurrence and improved postoperative SNOT-22, VAS, and Lund-Kennedy scores compared with surgery alone in patients with CRSwNP. However, these findings should be interpreted cautiously because endotype-specific effects, corticosteroid delivery methods, surgical extent, and long-term symptomatic recurrence were not consistently reported.
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