ReviewCommunications biology2026
Exploring the multifaceted Dbf4-dependent kinase from temporal, spatial, and substrate repertoire perspectives.
Review in Communications biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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2 authors.
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Abstract
The Dbf4‑dependent kinase (DDK), composed of the catalytic subunit Cdc7 and the regulatory subunit Dbf4, is a serine/threonine kinase traditionally defined as an essential activator of DNA replication. Here, we review DDK function from three complementary perspectives: its temporal regulation during the cell cycle, its spatial organization on chromosomes, and its expanding substrate repertoire. These perspectives reveal that DDK acts beyond DNA replication, targeting proteins involved in chromosome segregation, DNA damage responses and homologous recombination. Together, they redefine DDK as multifunctional genome integrity kinase which coordinates cell cycle progression and genome stability offering a unique therapeutic potential in cancer therapy.
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