Evidence map›Paper›PMID 42337299›Full record

ArticleScientific reports2026

Juglone induces GSDME axis pyroptosis in osteosarcoma cells via the JNK/P38 MAPK pathway.

Jierui Zhao, Xingyu Zhao, Yue Lu, He Wang, Yuhan Zhang, Yi Wang, LiChun Xing, Yumiao Guo, Peng Peng, Wei Zhang and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Jierui Zhao *Faculty of Chinese Medicine, Macau University of Science and Technology, Macao, 999078, China.
Xingyu Zhao *Jilin Medical University, Jilin, 132013, China.
Yue LuJilin Medical University, Jilin, 132013, China.
He WangJilin Medical University, Jilin, 132013, China.
Yuhan ZhangChangchun University of Chinese Medicine Changchun city, Changchun, 132000, China.
Yi WangFaculty of Chinese Medicine, Macau University of Science and Technology, Macao, 999078, China.
LiChun XingJilin Medical University, Jilin, 132013, China.
Yumiao GuoJilin Medical University, Jilin, 132013, China.
Peng PengFaculty of Chinese Medicine, Macau University of Science and Technology, Macao, 999078, China. ppbbpwq@126.com.
Wei ZhangJilin Medical University, Jilin, 132013, China. jlmmczw@163.com.
Qibiao WuFaculty of Chinese Medicine, Macau University of Science and Technology, Macao, 999078, China. qbwu@must.edu.mo.

Funding

Guangdong Provincial Medical Science and Technology Research Fund B2025626Science and Technology Department of Jilin Provincial YDZJ202401003ZYTSthe Chinese Medicine Guangdong Laboratory HQCML-C-2024006)the Science and Technology Development Fund, Macau SAR 0098/2021/A2 and 0048/2023/AFJ
6 · The paper itself

Abstract

The MAPK signaling pathway plays a considerable role in cancer inhibition, and pyroptosis is a type of programmed cell death (PCD); thus, it is essential for cellular activity and cancer progression. Juglone can inhibit the viability and motility of cancer cells, but it is unclear whether it can induce pyroptosis in cancer cells, and the corresponding regulatory mechanisms are not well understood. This study explored the in vitro effects of juglone on OS cells, further revealing its ability to induce pyroptosis via the caspase-3/GSDME pathway. Moreover, juglone can regulate the GSDME pathway to induce both pyroptosis and apoptosis through the JNK/p38 pathway. These findings suggest that juglone has potential as a therapeutic agent for osteosarcoma.

Indexed as

Bone NeoplasmsMAP Kinase Signaling SystemNaphthoquinonesOsteosarcomap38 Mitogen-Activated Protein KinasesPyroptosisReceptors, EstrogenApoptosisCaspase 3Cell Line, TumorGasderminsHumansCaspase 3GasderminsGSDME protein, humanjugloneNaphthoquinonesp38 Mitogen-Activated Protein KinasesReceptors, Estrogen

Identifiers

PMID42337299
PMCPMC13578436

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.