Evidence map›Paper›PMID 42337251›Full record

ArticleThe Korean journal of pain2026

Propofol attenuates pain hypersensitivity and neuroinflammation in chronic constriction injury rats by regulating miR-1249-3p/VEGFA axis.

Hailin Zhao, Chuping Peng, Xiumei Zhu, Long Wang, Lu Ye

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Korean journal of pain, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Hailin ZhaoDepartment of Neurosurgery, Guangzhou Institute of Cancer Research, the Affiliated Cancer Hospital, Guangzhou Medical University, Guangzhou, China.ORCID https://orcid.org/0009-0006-8802-530X
Chuping PengDepartment of Nephrology and Rheumatology, The Affiliated Nanhua Hospital, Hengyang Medical School, University of South China, Hengyang, Hunan, China.ORCID https://orcid.org/0009-0009-8347-0238
Xiumei ZhuDepartment of Anesthesiology, Guannan County First People's Hospital, Lianyungang, China.ORCID https://orcid.org/0009-0000-7016-9782
Long WangDepartment of Pain Medicine, The First Medical Center, Chinese PLA General Hospital, Beijing, China.ORCID https://orcid.org/0000-0002-1488-4471
Lu YeDepartment of Anesthesiology, Guangzhou Eighth People's Hospital, Guangzhou Medical University, Guangzhou, China.ORCID https://orcid.org/0009-0003-7506-2847

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Neuropathic pain (NP), a disabling chronic condition with limited treatments, is recapitulated in the chronic constriction injury (CCI) rat model. The role of the miR-1249-3p/VEGFA (vascular endothelial growth factor A) axis in propofol-mediated analgesia remains unclear. Methods: AntagomiR-1249-3p, antagomiR-NC (negative control), a VEGFA-targeting siRNA, and si-NC were delivered intrathecally Results: The expression of miR-1249-3p decreased and VEGFA increased in the spinal cord of CCI rats (all Conclusions: These findings suggest that propofol may reduce behavioral signs of NP and suppress associated neuroinflammation in CCI rats by the miR-1249-3p/VEGFA axis.

Indexed as

AnimalDisease ModelsMicroRNAsNeuralgiaNeuroinflammatory DiseasesNF-kappa BPropofolSpinal CordVascular Endothelial Growth Factor A

Identifiers

PMID42337251
PMCPMC13327912

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.