Evidence map›Paper›PMID 42337235›Full record

ArticleNature communications2026

Spatial analyses implicate high stromal tumour-infiltrating CD8

Zak Kinsella, Chowdhury Arif Jahangir, Hannah Nyarkoah Nyarko, Daria Kalinska-Lysiak, Claudia Aura Gonzalez, Verena Murphy, Tony O'Grady, Joanna Fay, Katherine Sheehan, Arman Rahman and 8 more

Abstract read
In one paragraph

Article in Nature communications, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors.

Zak Kinsella *School of Pharmacy & Biomolecular Sciences, Royal College of Surgeons in Ireland, Dublin, Ireland. zakkinsella@rcsi.com.ORCID 0000-0002-6176-8895
Chowdhury Arif Jahangir *UCD Conway Institute, University College Dublin, Dublin, Ireland.
Hannah Nyarkoah Nyarko *School of Pharmacy & Biomolecular Sciences, Royal College of Surgeons in Ireland, Dublin, Ireland.
Daria Kalinska-Lysiak *School of Pharmacy & Biomolecular Sciences, Royal College of Surgeons in Ireland, Dublin, Ireland.ORCID 0000-0002-8440-6168
Claudia Aura GonzalezUCD Conway Institute, University College Dublin, Dublin, Ireland.
Verena MurphyCancer Trials Ireland, Dublin, Ireland.
Tony O'GradyDepartment of Pathology, Royal College of Surgeons in Ireland, Dublin, Ireland.
Joanna FayDepartment of Pathology, Royal College of Surgeons in Ireland, Dublin, Ireland.
Katherine SheehanDepartment of Pathology, Royal College of Surgeons in Ireland, Dublin, Ireland.
Arman RahmanUCD Conway Institute, University College Dublin, Dublin, Ireland.
John P CrownSt. Vincent's University Hospital, Dublin, Ireland.
Catherine M KellyMater Hospital, Dublin, Ireland.
Simon S McDadeJohnston Cancer Research Centre (JCRC), Queens University Belfast, Belfast, UK.ORCID 0000-0002-3024-4773
Ina WoodsDepartment of Physiology & Medical Physics, Centre for Systems Medicine, Royal College of Surgeons in Ireland, Dublin, Ireland.
Niamh M C ConnollyDepartment of Physiology & Medical Physics, Centre for Systems Medicine, Royal College of Surgeons in Ireland, Dublin, Ireland.
Jochen H M PrehnDepartment of Physiology & Medical Physics, Centre for Systems Medicine, Royal College of Surgeons in Ireland, Dublin, Ireland.ORCID 0000-0003-3479-7794
William M GallagherUCD Conway Institute, University College Dublin, Dublin, Ireland.
Darran P O'ConnorSchool of Pharmacy & Biomolecular Sciences, Royal College of Surgeons in Ireland, Dublin, Ireland.ORCID 0000-0002-8835-1547

Funding

Irish Cancer Society CCRC13GALScience Foundation Ireland (SFI) 18/SPP/3522
6 · The paper itself

Abstract

Female patients with ER

Indexed as

Breast NeoplasmsCD8-Positive T-LymphocytesLymphocytes, Tumor-InfiltratingReceptors, EstrogenBiomarkers, TumorErb-b2 Receptor Tyrosine KinasesFemaleHumansMiddle AgedNeoplasm Recurrence, LocalPrognosisProteomicsSpatial TranscriptomicsStromal CellsT-Cell ExhaustionTumor MicroenvironmentBiomarkers, TumorErb-b2 Receptor Tyrosine KinasesReceptors, Estrogen

Identifiers

PMID42337235
PMCPMC13291258

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.