Evidence map›Paper›PMID 42337148›Full record

ArticleMikrochimica acta2026

Non-invasive monitoring of hyperuricemia via a flexible SERS sensor with ultrahigh sensitivity.

Shurui Chen, Jiachen Weng, Hao Chang, Kaiming Xiao, Yaling Wu, Yudong Lu, Ruiyun You

Abstract read
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In one paragraph

Article in Mikrochimica acta, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Shurui ChenSchool of Materials and Chemical Engineering, Fuzhou Institute of Oceanography, Minjiang University, Fuzhou, 350108, Fujian, China.
Jiachen WengCollege of Chemistry and Materials Science, Fujian Provincial Key Laboratory of Advanced Oriented Chemical Engineer, Fujian Key Laboratory of Polymer Materials, Engineering Research Center of Industrial Biocatalysis, Fujian Province Higher Education Institutes, Fujian Normal University, Fuzhou, 350007, Fujian, China.
Hao ChangCollege of Chemistry and Materials Science, Fujian Provincial Key Laboratory of Advanced Oriented Chemical Engineer, Fujian Key Laboratory of Polymer Materials, Engineering Research Center of Industrial Biocatalysis, Fujian Province Higher Education Institutes, Fujian Normal University, Fuzhou, 350007, Fujian, China.
Kaiming XiaoSchool of Materials and Chemical Engineering, Fuzhou Institute of Oceanography, Minjiang University, Fuzhou, 350108, Fujian, China.
Yaling WuSchool of Materials and Chemical Engineering, Fuzhou Institute of Oceanography, Minjiang University, Fuzhou, 350108, Fujian, China. 2934@mju.edu.cn.
Yudong LuCollege of Chemistry and Materials Science, Fujian Provincial Key Laboratory of Advanced Oriented Chemical Engineer, Fujian Key Laboratory of Polymer Materials, Engineering Research Center of Industrial Biocatalysis, Fujian Province Higher Education Institutes, Fujian Normal University, Fuzhou, 350007, Fujian, China. luyd@fjnu.edu.cn.
Ruiyun YouCollege of Chemistry and Materials Science, Fujian Provincial Key Laboratory of Advanced Oriented Chemical Engineer, Fujian Key Laboratory of Polymer Materials, Engineering Research Center of Industrial Biocatalysis, Fujian Province Higher Education Institutes, Fujian Normal University, Fuzhou, 350007, Fujian, China. youruiyun@fjnu.edu.cn.

Funding

Fuzhou-Xiamen-Qian'an National Independent Innovation Demonstration Zone Collaborative Innovation Platform Project 2025E3002Fuzhou-Xiamen-Qian'an National Independent Innovation Demonstration Zone Collaborative Innovation Platform Project 2025-P-004Natural Science Foundation of Fujian Province 2025J01626Natural Science Foundation of Fujian Province 2025J08275
6 · The paper itself

Abstract

A high-performance, flexible surface-enhanced Raman scattering (SERS) sensing platform designed to detect key hyperuricemia (HUA) biomarkers in non-invasive biofluids is presented. The platform employs a bimetallic nanocomposite hydrogel fabricated via a semi-interpenetrating polymer network, wherein hydroxyethyl cellulose-stabilized gold nanorods are integrated with in situ-reduced silver nanoparticles from oxidized sodium alginate within a sodium alginate/polyacrylamide hybrid network. The hydrogel SERS substrate exhibits outstanding mechanical properties with a tensile strain of up to 911.37% and excellent swelling behavior, achieving equilibrium swelling ratios of 1919.74% in deionized water and 1822.97% in artificial urine. It achieves detection limits of 2.09 × 10

Indexed as

HyperuricemiaSpectrum Analysis, RamanUric AcidAcrylic ResinsAlginatesCelluloseGlucuronic AcidGoldHexuronic AcidsHumansHydrogelsHypoxanthineLimit of DetectionMetal NanoparticlesNanocompositesNanotubesAcrylic ResinsAlginatesCelluloseGlucuronic AcidGoldHexuronic AcidsHydrogelshydroxyethylcelluloseHypoxanthinePolyacrylamidesSilverUric AcidXanthineBimetallic nanomaterialsHyperuricemiaMultifunctional hydrogelSemi-interpenetrating polymer networkSurface-enhanced Raman scattering

Identifiers

PMID42337148

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.