ArticleJournal of mathematical biology2026
Superinfection and the hypnozoite reservoir for Plasmodium vivax: a multitype branching process approximation.
Article in Journal of mathematical biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Plasmodium vivax malaria is a mosquito-borne disease of significant public health importance. A defining feature of the within-host biology of P. vivax is the accrual of a hypnozoite reservoir, comprising a bank of quiescent parasites in the liver that are capable of causing relapsing blood-stage infections upon activation. Superinfection, characterised by composite blood-stage infections with parasites derived from multiple mosquito inoculation or hypnozoite activation events, is another important attribute. We have previously developed a stochastic epidemic model of P. vivax malaria, formulated as a Markov population process with countably infinitely-many types, that is adjusted for both hypnozoite accrual and blood-stage superinfection. Here, we construct a Markovian branching process with countably infinitely-many types to approximate the early stages of this epidemic model. With
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