Evidence map›Paper›PMID 42336938›Full record

ArticleScientific reports2026

HB reduces inflammation in HUVECs via the Nrf2/HO-1 axis by inhabiting apoptosis and oxidative stress.

Xiaoyu Zhang, Chunlin Cong, Hui Cao, Lina Zhu, Na Cheng, Shuang Wu, Peina Geng, Lili Cao, Rui Chen, Zhaoxiu Liu and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Xiaoyu Zhang *Department of Geriatrics, 71st Group Army Hospital of People's Liberation Army of China, Xuzhou, China.
Chunlin Cong *Department of Geriatrics, 71st Group Army Hospital of People's Liberation Army of China, Xuzhou, China.
Hui CaoDepartment of Obstetrics and Gynecology, 71st Group Army Hospital of People's Liberation Army of China, Xuzhou, China.
Lina ZhuDepartment of Obstetrics and Gynecology, 71st Group Army Hospital of People's Liberation Army of China, Xuzhou, China.
Na ChengDepartment of Obstetrics and Gynecology, 71st Group Army Hospital of People's Liberation Army of China, Xuzhou, China.
Shuang WuDepartment of Obstetrics and Gynecology, 71st Group Army Hospital of People's Liberation Army of China, Xuzhou, China.
Peina GengDepartment of Geriatrics, 71st Group Army Hospital of People's Liberation Army of China, Xuzhou, China.
Lili CaoDepartment of Geriatrics, 71st Group Army Hospital of People's Liberation Army of China, Xuzhou, China.
Rui ChenDepartment of Geriatrics, 71st Group Army Hospital of People's Liberation Army of China, Xuzhou, China.
Zhaoxiu LiuDepartment of Gastroenterology, Nantong University Affiliated Hospital, 20 Xisi Road, Nantong, 226001, Jiangsu, China.
Peng WuDepartment of Obstetrics and Gynecology, 71st Group Army Hospital of People's Liberation Army of China, Xuzhou, China. 41554127@qq.com.
Linyu ShiDepartment of Obstetrics and Gynecology, 71st Group Army Hospital of People's Liberation Army of China, Xuzhou, China. 15262732500@163.com.

Funding

National Natural Science Foundation of China 82000497
6 · The paper itself

Abstract

Existing research data indicate that Hemoglobin (HB) can ameliorate oxidative stress, fibrosis, and inflammatory responses. Given that traditional cardiovascular and cerebrovascular diseases are associated with chronic vascular injury and oxidative stress, this study aimed to investigate the effect of HB on vascular inflammation and explore its potential for vascular protection. The study employed the CCK-8 assay, Western blot, immunofluorescence, PCR, as well as assessments of reactive oxygen species (ROS), malondialdehyde (MDA), Caspase-3 activity, and flow cytometry. Apoptosis was detected by flow cytometry using Annexin V-FITC staining, and intracellular reactive oxygen species (ROS) levels were measured using the fluorescent probe DCFDA-DA. HB significantly reduced the expression of inflammatory cytokines (TNF‑α, IL‑6, IL‑1β) in H

Indexed as

ApoptosisHeme Oxygenase-1HemoglobinsHuman Umbilical Vein Endothelial CellsInflammationNF-E2-Related Factor 2Oxidative StressCytokinesHumansHydrogen PeroxideReactive Oxygen SpeciesSignal TransductionCytokinesHeme Oxygenase-1HemoglobinsHMOX1 protein, humanHydrogen PeroxideNFE2L2 protein, humanNF-E2-Related Factor 2Reactive Oxygen SpeciesAnti-inflammatory effectEndothelial dysfunctionHeterophyllin BNrf2/HO-1

Identifiers

PMID42336938
PMCPMC13578324

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.