Evidence map›Paper›PMID 42336903›Full record

ArticleScientific reports2026

Green synthesis, one-pot reaction, biological evaluation, and molecular docking studies of new pyrazolo[3,4-d]tetrazolo[1,5-a]pyrimidine derivatives.

Mohamed Shaker S Adam, Ibrahim Alfurayj, Mostafa Y Nassar, Ahmed Khalil, Moumen S Kamel, Tarek El-Dabea, Mohammed Er-Rajy, Mahmoud Abd El Aleem Ali Ali El-Remaily

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Article in Scientific reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Mohamed Shaker S AdamDepartment of Chemistry, College of Science, King Faisal University, P.O. Box 400, Al-Ahsa, 31982, Saudi Arabia. madam@kfu.edu.sa.
Ibrahim AlfurayjDepartment of Chemistry, College of Science, King Faisal University, P.O. Box 400, Al-Ahsa, 31982, Saudi Arabia.
Mostafa Y NassarDepartment of Chemistry, College of Science, King Faisal University, P.O. Box 400, Al-Ahsa, 31982, Saudi Arabia.
Ahmed KhalilDepartment of Chemistry, College of Science, King Faisal University, P.O. Box 400, Al-Ahsa, 31982, Saudi Arabia.
Moumen S KamelDepartment of Chemistry, Faculty of Science, Sohag University, Sohag, 82524, Egypt.
Tarek El-DabeaDepartment of Chemistry, Faculty of Science, King Salman International University, Ras Sudr, Sinai, 46612, Egypt.
Mohammed Er-RajySystems Engineering, Modeling and Analysis Laboratory (LIMAS), Faculty of Sciences, Sidi Mohamed Ben Abdellah University, Dhar El Mahraz, Fez, Morocco.
Mahmoud Abd El Aleem Ali Ali El-RemailyDepartment of Chemistry, Faculty of Science, Sohag University, Sohag, 82524, Egypt. msremaily@yahoo.com.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The work represents a synthesized strategy for a range of novel pyrazolotriazole pyrimidine derivatives using a one-pot, three-component reaction involving 5-aminotetrazole, aromatic aldehydes, and 3-methyl-5-pyrazolone. The structure of the synthesized compounds was confirmed by IR, NMR, and mass spectroscopies. Their anticancer properties were assessed against various cell lines using the in vitro MTT method. Among the tested compounds, 4c demonstrated the most potent antitumor activity. Compound 4c showed an IC

Indexed as

Antineoplastic AgentsGreen Chemistry TechnologyPyrazolesPyrimidinesAntioxidantsCell Line, TumorHumansMicrobial Sensitivity TestsMolecular Docking SimulationStructure-Activity RelationshipAntineoplastic AgentsAntioxidantsPyrazolesPyrimidinesAnticancerAntimicrobialAntioxidantMolecular dockingPyrazolo-triazole-pyrimidine derivativesTherapeutic agents

Identifiers

PMID42336903
PMCPMC13342643

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.