Evidence map›Paper›PMID 42336868›Full record

ReviewNPJ biofilms and microbiomes2026

Oxygen homeostasis: new insight of gut microbiota-host interactions.

Zhipeng Yang, Juan Yang, Jian Peng, Hongkui Wei

Abstract readReview
PubMed Publisher
In one paragraph

Review in NPJ biofilms and microbiomes, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Zhipeng YangDepartment of Animal Nutrition and Feed Science, College of Animal Science and Technology, Huazhong Agricultural University, Wuhan, China.
Juan YangDepartment of Animal Nutrition and Feed Science, College of Animal Science and Technology, Huazhong Agricultural University, Wuhan, China.
Jian PengDepartment of Animal Nutrition and Feed Science, College of Animal Science and Technology, Huazhong Agricultural University, Wuhan, China.
Hongkui WeiDepartment of Animal Nutrition and Feed Science, College of Animal Science and Technology, Huazhong Agricultural University, Wuhan, China. weihongkui@mail.hzau.edu.cn.

Funding

China Agriculture Research System of MOF and MARA CARS-36Funds of the National Natural Science Foundation of China U22A20511Hubei Province Science and Technology Innovation Major Project 2022BBA0012National Natural Science Foundation of China National Natural Science Foundation of ChinaTechnical Team for Genetic Improvement and Healthy Breeding of Livestock and Poultry 2025-620-000-001-026
6 · The paper itself

Abstract

Oxygen homeostasis is a key ecological factor shaping microbial composition, epithelial function, and immune balance in the gut. Spatial and developmental oxygen gradients drive the transition from facultative to obligate anaerobes. Gut hypoxia is maintained by epithelial oxygen consumption and microbial metabolism, forming a positive feedback loop that supports barrier integrity and immune homeostasis. Disruption by inflammation, antibiotics, or diet elevates oxygen availability, promoting dysbiosis, pathogen expansion, and disease risk.

Indexed as

Gastrointestinal MicrobiomeHomeostasisHost Microbial InteractionsOxygenAnimalsHost-Pathogen InteractionsHumansIntestinal Barrier FunctionOxygen

Identifiers

PMID42336868

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.