Evidence map›Paper›PMID 42336866›Full record

ArticleNPJ vaccines2026

Suppressor tRNA-mediated conditionally replicating live vaccine effectively protects pigs against Seneca Valley virus challenge.

Xinghua Chen, Xiangmin Li, Nan Cao, Meiting Li, Linxing Tian, Pan Hu, Jian Du, Lingai Meng, Chao Zhang, Chunwei Li and 3 more

Abstract read
PubMed Publisher
In one paragraph

Article in NPJ vaccines, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Xinghua ChenNational Key Laboratory of Agricultural Microbiology, Hubei Hongshan Laboratory, Huazhong Agricultural University, Wuhan, Hubei, China.
Xiangmin LiNational Key Laboratory of Agricultural Microbiology, Hubei Hongshan Laboratory, Huazhong Agricultural University, Wuhan, Hubei, China.
Nan CaoNational Key Laboratory of Agricultural Microbiology, Hubei Hongshan Laboratory, Huazhong Agricultural University, Wuhan, Hubei, China.
Meiting LiNational Key Laboratory of Agricultural Microbiology, Hubei Hongshan Laboratory, Huazhong Agricultural University, Wuhan, Hubei, China.
Linxing TianNational Key Laboratory of Agricultural Microbiology, Hubei Hongshan Laboratory, Huazhong Agricultural University, Wuhan, Hubei, China.
Pan HuNational Key Laboratory of Agricultural Microbiology, Hubei Hongshan Laboratory, Huazhong Agricultural University, Wuhan, Hubei, China.
Jian DuNational Key Laboratory of Agricultural Microbiology, Hubei Hongshan Laboratory, Huazhong Agricultural University, Wuhan, Hubei, China.
Lingai MengNational Key Laboratory of Agricultural Microbiology, Hubei Hongshan Laboratory, Huazhong Agricultural University, Wuhan, Hubei, China.
Chao ZhangNational Key Laboratory of Agricultural Microbiology, Hubei Hongshan Laboratory, Huazhong Agricultural University, Wuhan, Hubei, China.
Chunwei LiNational Key Laboratory of Agricultural Microbiology, Hubei Hongshan Laboratory, Huazhong Agricultural University, Wuhan, Hubei, China.
Zihui HuNational Key Laboratory of Agricultural Microbiology, Hubei Hongshan Laboratory, Huazhong Agricultural University, Wuhan, Hubei, China.
Jinyan ZhangNational Key Laboratory of Agricultural Microbiology, Hubei Hongshan Laboratory, Huazhong Agricultural University, Wuhan, Hubei, China.
Ping QianNational Key Laboratory of Agricultural Microbiology, Hubei Hongshan Laboratory, Huazhong Agricultural University, Wuhan, Hubei, China. qianp@mail.hzau.edu.cn.

Funding

National Key R D Program of China 2024YFD1800505National Natural Science Foundation of China 32072841
6 · The paper itself

Abstract

Seneca Valley virus (SVV) causes porcine idiopathic vesicular disease, severely endangering the economic benefits of the swine industry. Artificial control of viral replication via the introduction of premature termination codons (PTCs) into the viral genome using suppressor tRNAs (sup-tRNAs) is a promising strategy for developing efficient vaccines. In this study, optimization of the SVV 3D gene for the incorporation of multiple PTCs resulted in a progeny virus harboring three PTCs with high replicative capacity and genetic stability. In mouse and pig models, compared with inactivated vaccines, the SVV-PTC vaccination elicited high antibody titers at 14 days post-primary immunization and induced a stronger Th1-biased cellular immune response. We further validated the safety and protective efficacy of the SVV-PTC vaccine candidate in swine models, confirming its complete attenuation in vivo, absence of horizontal transmission, and protective efficacy comparable to that of the commercial inactivated SVV vaccine. In conclusion, the development of live but replication-incompetent attenuated vaccines using sup-tRNA is a promising prevention and control strategy, providing a new insight for the development of novel SVV vaccines.

Identifiers

PMID42336866

What OpenQuestion holds

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.