ArticleScientific data2026
Chromosome-level genome assembly and DNA methylation data of the oleaginous astaxanthin-producing alga Chromochloris zofingiensis.
Article in Scientific data, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Chromochloris zofingiensis has emerged as a promising economic microalgal strain owing to its capacity for the integrated production of triacylglycerol (TAG) and astaxanthin. To advance its development as a robust model alga for studying lipid metabolism and astaxanthin biosynthesis, we performed a comprehensive genome sequencing strategy integrating Nanopore long-reads and Illumina short-reads, together with Hi-C and PacBio full-length transcriptome sequencing. This enabled an improved chromosome-level genome assembly comprising of 17 chromosomes with a total size of 57.09 Mb and a scaffold N50 of 3.18 Mb. In total, 94.85% of the assembled sequences are anchored on 17 chromosomes. Compared to the sole published genome draft, the new assembly exhibits substantial enhancements in completeness and accuracy, with 12,480 protein-coding genes predicted. Furthermore, we presented the first genome-wide DNA methylation landscape of C. zofingiensis through the combined analysis of Nanopore and Bisulfite sequencing data. In summary, this improved, chromosome-scale genome provides a valuable genetic resource for in-depth molecular research and genetic engineering of this oleaginous astaxanthin-producing alga.
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