Evidence map›Paper›PMID 42336761›Full record

ArticleEBioMedicine2026

A cross-sectional study of oxidative stress pathway genotypes and their interactions with environmental pollutant levels identifies associations with gene expression and lung function.

Shuangjia Xue, Seyed Mehdi Nouraie, Jiebiao Wang, Xingnan Li, Deborah Meyers, Eugene R Bleecker, Victor E Ortega, Mario Castro, Loren C Denlinger, Serpil Erzurum and 9 more

Abstract readMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Article in EBioMedicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors.

Shuangjia XueDepartment of Environmental and Occupational Health, University of Pittsburgh, Pittsburgh, PA, USA.
Seyed Mehdi NouraieDivision of Pulmonary, Allergy and Critical Care Medicine, Department of Medicine, University of Pittsburgh, Pittsburgh, PA, USA.
Jiebiao WangDepartment of Biostatistics and Health Data Science, University of Pittsburgh, Pittsburgh, PA, USA.
Xingnan LiDepartment of Medicine, Division of Pulmonary, Critical Care and Sleep Medicine, Division of Data-Driven and Digital Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Deborah MeyersDivision of Genetics, Genomics and Precision Medicine, Department of Medicine, University of Arizona, Tucson, AZ, USA.
Eugene R BleeckerDivision of Genetics, Genomics and Precision Medicine, Department of Medicine, University of Arizona, Tucson, AZ, USA.
Victor E OrtegaCenter for Individualized Medicine, Mayo Clinic, Phoenix, AZ, USA.
Mario CastroDepartment of Medicine, University of Kansas Medical Center, Kansas City, KS, USA.
Loren C DenlingerDivision of Pulmonary and Critical Care, School of Medicine and Public Health, University of Wisconsin, Madison, WI, USA.
Serpil ErzurumLerner Research Institute, Cleveland Clinic, Cleveland, OH, USA.
Elliot IsraelDepartment of Medicine, Harvard University School of Medicine, Boston, MA, USA; Division of Pulmonary and Critical Care Medicine, Brigham and Women's Hospital, Boston, MA, USA.
Prescott WoodruffSchool of Medicine, University of California San Francisco, San Francisco, CA, USA.
Wendy C MooreDepartment of Pulmonary, Critical Care, Allergy and Immunologic Diseases, Wake Forest School of Medicine, Winston-Salem, NC, USA.
Stephanie ChristensonSchool of Medicine, University of California San Francisco, San Francisco, CA, USA.
John FahySchool of Medicine, University of California San Francisco, San Francisco, CA, USA.
Kaharu SuminoDivision of Pulmonary and Critical Care Medicine, Washington University School of Medicine, St. Louis, MO, USA.
Nizar JarjourDivision of Pulmonary and Critical Care, School of Medicine and Public Health, University of Wisconsin, Madison, WI, USA.
Bruce LevyDivision of Pulmonary and Critical Care Medicine, Brigham and Women's Hospital, Boston, MA, USA.
Sally E WenzelDepartment of Environmental and Occupational Health, University of Pittsburgh, Pittsburgh, PA, USA; Division of Pulmonary, Allergy, Critical Care, and Sleep Medicine, Department of Medicine, University of Pittsburgh, Pittsburgh, PA, USA. Electronic address: swenzel@pitt.edu.

Funding

Rapid saliva antigen test for SARS-CoV-2 detectionU01HL146002 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI ARONICA, MARK A, CASTRO, MARIO · 2019 to 2023
$17.3M
Clinical Coordinating Center for the Severe Asthma Research Program (SARP)U10HL109086 · NHLBI · PENNSYLVANIA STATE UNIV HERSHEY MED CTR · PI MAUGER, DAVID T. · 2011 to 2017
$8.1M
AMSA: ALXR/FBR Mediated Signaling in Severe AsthmaU10HL109172 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI ISRAEL, ELLIOT, LEVY, BRUCE D · 2011 to 2016
$4.2M
Airway redox biochemistry as a deteriminant of asthma phenotype during adolescen*U10HL109250 · NHLBI · UNIVERSITY OF VIRGINIA · PI ERZURUM, SERPIL C., GASTON, BENJAMIN · 2011 to 2016
$4.2M
Clinical and Molecular Phenotypes of Severe AsthmaU10HL109146 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI FAHY, JOHN V · 2011 to 2016
$4.0M
Implications and Stability of Clinical and Molecular Phenotypes of Severe AsthmaU10HL109152 · NHLBI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI WENZEL, SALLY E · 2011 to 2016
$3.9M
Stability of Severe Asthma Phenotypes: Impact of ExacerbationsU10HL109168 · NHLBI · UNIVERSITY OF WISCONSIN-MADISON · PI JARJOUR, NIZAR N · 2011 to 2016
$3.9M
Severe Asthma Research Program (SARP)-Washington UniversityU10HL109257 · NHLBI · WASHINGTON UNIVERSITY · PI CASTRO, MARIO · 2011 to 2016
$3.8M
Longitudinal Phenomics and Genetics of Severe AsthmaU10HL109164 · NHLBI · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI BLEECKER, EUGENE ROLAND, MEYERS, DEBORAH A. · 2011 to 2016
$3.8M
NHLBI NIH HHS U01 HL146002NHLBI NIH HHS U10 HL109086NHLBI NIH HHS U10 HL109146NHLBI NIH HHS U10 HL109152NHLBI NIH HHS U10 HL109164NHLBI NIH HHS U10 HL109168NHLBI NIH HHS U10 HL109172NHLBI NIH HHS U10 HL109250NHLBI NIH HHS U10 HL109257
6 · The paper itself

Abstract

backgroundAsthma is a heterogeneous disease influenced by genetic and environmental factors. Fine particulate matter (PM

methodsWe analysed data on 948 adults with asthma from the Severe Asthma Research Program (SARP), linking ZIP-code-level PM

findingsHigher PM

interpretationThis study identified 20 SNPs in oxidative stress pathway genes that modify the effect of PM

fundingSupported by NIH grants.

Indexed as

Air PollutantsAsthmaOxidative StressParticulate MatterAdultAir PollutionCross-Sectional StudiesEnvironmental ExposureEpithelial CellsFemaleForced Expiratory VolumeGene-Environment InteractionGene Expression RegulationGenotypeHumansLungAir PollutantsParticulate MatterAsthmaGenexenvironmentPM(2.5)PollutionSpirometry

Identifiers

PMID42336761
PMCPMC13347616

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.