ArticleShock (Augusta, Ga.)2026
Plasma Regulates Homeostatic Pulmonary Endothelial Signaling to Mitigate Vascular Leak Following Polytrauma and Hemorrhagic Shock.
Article in Shock (Augusta, Ga.), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
introductionIn hemorrhagic shock (HS), plasma resuscitation preserves vascular integrity and protects against trauma-induced coagulopathy and organ injury. Despite demonstrated clinical benefit, the endothelial mechanisms underlying plasma resuscitation remain incompletely defined. This study investigated endothelial-specific responses to plasma resuscitation to identify targetable pathways that promote vascular repair after traumatic injury.
methodsA murine model of severe polytrauma-HS (PT/HS) with demonstrable vascular endotheliopathy by 24 hours was used to compare pulmonary vascular endothelial cell (EC) responses to resuscitation with lactated Ringer's solution (LR) relative to fresh frozen plasma (FFP). Whole blood was collected for inflammatory biomarker analysis, and pulmonary vascular leak was quantified by dextran extravasation. Pulmonary EC glycocalyx structure was assessed by transmission electron microscopy and immunofluorescence. Spatial transcriptomic profiling of pulmonary ECs was performed using a GeoMx Digital Spatial Profiler. Key transcriptomic findings related to mitochondrial biogenesis were validated by immunostaining and by treating primary human lung EC with FFP or LR.
resultsAt 24 hours after injury, FFP reduced systemic inflammatory cytokines, pulmonary innate immune cell infiltration, and PT/HS-induced vascular leak compared to LR. Plasma levels of syndecan-1 and hyaluronan were decreased, consistent with a reduction in pulmonary glycocalyx shedding. Although few differences in EC glycocalyx-related genes were detected, pathway analysis revealed enrichment of cellular bioenergetics and metabolic recovery pathways in ECs after FFP, whereas LR was associated with oxidative stress and inflammatory signaling. FFP enhanced mitochondrial content in pulmonary EC after PT/HS and in treated human EC compared to LR-treated controls.
conclusionsFFP resuscitation after PT/HS reduces systemic inflammation and preserves pulmonary vascular barrier function, potentially through promotion of mitochondrial signaling, metabolic recovery, and endothelial stress regulation.
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