ArticleMolecular cell2026
A dynamic RNA hub facilitates activation-induced cytidine deaminase recruitment to the immunoglobulin heavy-chain locus.
Article in Molecular cell, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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Who cites it
3 citing papers in PubMed.
- Article
- AID self-assembly and multistranded DNA binding drive synapsis in class switch recombination.Nucleic acids research · 2026Article
- Human antibody heavy chain variable region exon interacts with 3' regulatory region to form a stable somatic hypermutation center.bioRxiv : the preprint server for biology · 2026Article
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6 authors.
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Abstract
Activation-induced cytidine deaminase (AID) converts cytosines to uracils in actively transcribed switch regions to initiate the formation of DNA double-strand breaks required for immunoglobulin class switch recombination (CSR). How AID targets switch regions remains a key unanswered question. Using multimodal live-cell single-molecule imaging of mouse B cells, we demonstrate that intronic switch regions promote robust transcription by enhancing polymerase engagement and persistent transcriptional bursts, resulting in the formation of a dynamic RNA hub consisting of numerous nascent switch transcripts tethered to the IgH locus. We further demonstrate that AID interacts with switch region RNA in vivo and that this interaction is required for recruitment of AID to the IgH locus. Together, our findings show that the RNA hub formed by nascent switch region transcripts may be a part of a "class switch recombination center" and drives the recruitment of AID to the IgH locus to initiate CSR.
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