Evidence map›Paper›PMID 42335894›Full record

ArticleCell metabolism2026

Methionine-supplemented longevity diet increases growth hormone, GLP-1, and FGF21; reduces frailty; and promotes healthspan.

Maura Fanti, Sebastian Brandhorst, Gerardo Navarrete, Arnold Diaz, Giacomo Giuliani, Dolly Chowdhury, Gabriel C Antunes, Todd E Morgan, Louis Dubeau, Valentina Villani and 4 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cell metabolism, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Maura FantiLongevity Institute, Leonard Davis School of Gerontology, University of Southern California, Los Angeles, CA, USA.
Sebastian BrandhorstLongevity Institute, Leonard Davis School of Gerontology, University of Southern California, Los Angeles, CA, USA.
Gerardo NavarreteLongevity Institute, Leonard Davis School of Gerontology, University of Southern California, Los Angeles, CA, USA.
Arnold DiazLongevity Institute, Leonard Davis School of Gerontology, University of Southern California, Los Angeles, CA, USA.
Giacomo GiulianiLongevity Institute, Leonard Davis School of Gerontology, University of Southern California, Los Angeles, CA, USA.
Dolly ChowdhuryLongevity Institute, Leonard Davis School of Gerontology, University of Southern California, Los Angeles, CA, USA.
Gabriel C AntunesLaboratory of Molecular Biology of Exercise, University of Campinas, Limeira, São Paulo, Brazil.
Todd E MorganLongevity Institute, Leonard Davis School of Gerontology, University of Southern California, Los Angeles, CA, USA.
Louis DubeauDepartment of Pathology, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.
Valentina VillaniGOFARR Laboratory, Children's Hospital Los Angeles, Division of Urology, Saban Research Institute, Los Angeles, CA, USA.
Laura PerinGOFARR Laboratory, Children's Hospital Los Angeles, Division of Urology, Saban Research Institute, Los Angeles, CA, USA; Department of Surgery, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.
Vasanti S MalikDepartment of Nutritional Sciences, University of Toronto, Toronto, ON, Canada; Department of Nutrition, Harvard T.H. Chan School of Public Health, Boston, MA, USA.
Frank B HuDepartment of Nutrition, Harvard T.H. Chan School of Public Health, Boston, MA, USA; Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA, USA.
Valter D LongoLongevity Institute, Leonard Davis School of Gerontology, University of Southern California, Los Angeles, CA, USA. Electronic address: vlongo@usc.edu.

Funding

Role of the Mitochondrial Peptide Humanin in Regulating Aging and HealthspanP01AG055369 · NIA · UNIVERSITY OF SOUTHERN CALIFORNIA · PI BRANDHORST, SEBASTIAN, COHEN, PINCHAS · 2018 to 2023
$12.4M
NON-PARENCHYMAL LIVER CELL CORER24AA012885 · NIAAA · UNIVERSITY OF SOUTHERN CALIFORNIA · PI TSUKAMOTO, HIDEKAZU · 2001 to 2025
$8.1M
Dietary protection against APOE4 phenotypes in aging and Alzheimer'sR01AG084485 · NIA · UNIVERSITY OF SOUTHERN CALIFORNIA · PI CHRISTIAN J PIKE · 2023 to 2026
$4.0M
NIAAA NIH HHS R24 AA012885NIA NIH HHS P01 AG055369NIA NIH HHS R01 AG084485
6 · The paper itself

Abstract

Southern European countries have some of the highest life expectancies in the world, yet they display relatively high frailty. We examined different diets to identify compositions that promote both healthspan and strength in mice. The western and ketogenic diets increased fat mass and frailty and increased either cholesterol or insulin resistance, whereas a low-protein longevity diet, modeling the traditional Mediterranean and Okinawan diets but supplemented with methionine (LDMM), reduced fat mass and frailty while improving cardiometabolic markers. LDMM reduced insulin-like growth factor (IGF)-1 while increasing growth hormone, GLP-1, and fibroblast growth factor (FGF)21, which was required for fat loss and insulin sensitivity. Bimonthly cycles of a 4-day fasting-mimicking diet instead improved metabolic markers. A cross-sectional analysis of epidemiological data from over 200,000 men and women indicates that those with the highest animal protein intake tended to have a healthier lifestyle but had approximately double the prevalence of type 2 diabetes compared with those in the lowest intake group. These findings indicate that mostly plant-based low-amino-acid diets have the most potent effects on healthspan but require moderate methionine intake to minimize frailty.

Indexed as

Fibroblast Growth FactorsFrailtyGlucagon-Like Peptide 1Growth HormoneLongevityMethionineAnimalsDietDietary SupplementsFemaleHumansInsulin ResistanceMaleMiceMice, Inbred C57BLfibroblast growth factor 21Fibroblast Growth FactorsGlucagon-Like Peptide 1Growth HormoneMethioninedietary interventionFGF21GHGLP-1IGF-1insulin sensitivitylongevitymethionineobesityweight loss

Identifiers

PMID42335894
PMCPMC13480414

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.