Evidence map›Paper›PMID 42335893›Full record

ArticleImmunity2026

Monocytic niches escape T cell surveillance and promote Mycobacterium tuberculosis persistence in lymph nodes.

Elya A Shamskhou, Fergal J Duffy, Lauren M Cross, Courtney R Plumlee, Benjamin H Gern, Holly W Barrett, Alan H Diercks, Sara B Cohen, Ramya Sivakumar, John D Aitchison and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Immunity, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Elya A ShamskhouCenter for Global Infectious Disease Research, Seattle Children's Research Institute, Seattle, WA, USA; Department of Immunology, University of Washington, Seattle, WA, USA.
Fergal J DuffyCenter for Global Infectious Disease Research, Seattle Children's Research Institute, Seattle, WA, USA.
Lauren M CrossCenter for Global Infectious Disease Research, Seattle Children's Research Institute, Seattle, WA, USA.
Courtney R PlumleeCenter for Global Infectious Disease Research, Seattle Children's Research Institute, Seattle, WA, USA.
Benjamin H GernCenter for Global Infectious Disease Research, Seattle Children's Research Institute, Seattle, WA, USA; Department of Pediatrics, University of Washington, Seattle, WA, USA.
Holly W BarrettCenter for Global Infectious Disease Research, Seattle Children's Research Institute, Seattle, WA, USA.
Alan H DiercksCenter for Global Infectious Disease Research, Seattle Children's Research Institute, Seattle, WA, USA.
Sara B CohenCenter for Global Infectious Disease Research, Seattle Children's Research Institute, Seattle, WA, USA.
Ramya SivakumarDepartment of Immunology, University of Washington, Seattle, WA, USA.
John D AitchisonCenter for Global Infectious Disease Research, Seattle Children's Research Institute, Seattle, WA, USA; Department of Pediatrics, University of Washington, Seattle, WA, USA.
Vitaly V GanusovHost-Pathogen Interactions Program, Texas Biomedical Research Institute, San Antonio, TX, USA.
Kevin B UrdahlCenter for Global Infectious Disease Research, Seattle Children's Research Institute, Seattle, WA, USA; Department of Immunology, University of Washington, Seattle, WA, USA; Department of Pediatrics, University of Washington, Seattle, WA, USA. Electronic address: kevin.urdahl@seattlechildrens.org.
Michael Y GernerDepartment of Immunology, University of Washington, Seattle, WA, USA. Electronic address: gernermy@uw.edu.

Funding

IMMUNE MECHANISMS OF PROTECTION AGAINST MYCOBACTERIUM TUBERCULOSIS CENTER (IMPAC-TB) - SARS-CoV-2 RELATED RESEARCH75N93019C00070 · NIAID · SEATTLE CHILDREN'S HOSPITAL · PI URDAHL, KEVIN · 2019 to 2025
$86.6M
Systems Biology, Bioinformatics, & Data IntegrationU19AI162583 · NIAID · UNIVERSITY OF WASHINGTON · PI COX, JEFFERY S, HAWN, THOMAS R · 2021 to 2025
$13.0M
The Roles of Lymphoid Tissue Microenvironments in Guiding the Immune ResponseR01AI134713 · NIAID · UNIVERSITY OF WASHINGTON · PI Michael Gerner · 2018 to 2026
$4.4M
Basic Training at the Intersection of Innate and Adaptive Immunity in DiseaseT32AI106677 · NIAID · UNIVERSITY OF WASHINGTON · PI GALE, MICHAEL, GOVERMAN, JOAN M · 2013 to 2022
$2.1M
NIAID NIH HHS 75N93019C00070NIAID NIH HHS R01 AI134713NIAID NIH HHS T32 AI106677NIAID NIH HHS U19 AI162583NIH HHS 75N93019C00070
6 · The paper itself

Abstract

Lung-draining mediastinal lymph nodes (medLNs) are critical for Mycobacterium tuberculosis (Mtb) pathogenesis, serving both as sites of T cell priming and, paradoxically, reservoirs for long-term bacterial persistence. To understand this dichotomy, we examined myeloid and CD4

Indexed as

Lymph NodesMonocytesMycobacterium tuberculosisTh1 CellsTuberculosisAnimalsBCG VaccineDendritic CellsImmunologic SurveillanceLymphocyte ActivationMiceMice, Inbred C57BLBCG Vaccinebacterial persistenceBCG vaccinationdendritic cellsinnate cell responseslymph node architecturemonocyte-derived cellsMycobacterium tuberculosissingle-cell RNA sequencingT cell primingtype I interferon

Identifiers

PMID42335893
PMCPMC13379055

What OpenQuestion holds

Textmetadata
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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.