Evidence map›Paper›PMID 42335653›Full record

ArticleJournal of lipid research2026

Fatty acid-binding protein 5 deficiency impairs alveolar macrophage function and metabolism.

Jack H Ratliff, Katja Aviszus, Sophia Addi, Manale El Kharbili, Steven Fujaros, Sarah K Sasse, Brian E Vestal, Anthony N Gerber, Evgenia Dobrinskikh, Fabienne Gally

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of lipid research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Jack H RatliffDepartment of Immunology and Genomic Medicine, National Jewish Health, Denver, Colorado, USA.
Katja AviszusDepartment of Immunology and Genomic Medicine, National Jewish Health, Denver, Colorado, USA.
Sophia AddiDepartment of Immunology and Genomic Medicine, National Jewish Health, Denver, Colorado, USA.
Manale El KharbiliDepartment of Immunology and Genomic Medicine, National Jewish Health, Denver, Colorado, USA.
Steven FujarosDepartment of Immunology and Genomic Medicine, National Jewish Health, Denver, Colorado, USA.
Sarah K SasseDepartment of Medicine, National Jewish Health, Denver, Colorado, USA; Department of Medicine, University of Kentucky, Lexington, Kentucky, USA.
Brian E VestalDepartment of Immunology and Genomic Medicine, National Jewish Health, Denver, Colorado, USA.
Anthony N GerberDepartment of Immunology and Genomic Medicine, National Jewish Health, Denver, Colorado, USA; Department of Medicine, National Jewish Health, Denver, Colorado, USA; Department of Medicine, University of Kentucky, Lexington, Kentucky, USA; Department of Medicine, University of Colorado, Aurora, Colorado, USA.
Evgenia DobrinskikhDepartment of Medicine, University of Colorado, Aurora, Colorado, USA; Department of Pediatrics, University of Colorado, Aurora, Colorado, USA.
Fabienne GallyDepartment of Immunology and Genomic Medicine, National Jewish Health, Denver, Colorado, USA; Department of Medicine, University of Colorado, Aurora, Colorado, USA; Department of Immunology and Microbiology, University of Colorado, Aurora, Colorado, USA. Electronic address: gallyf@njhealth.org.

Funding

Role of FABP5 in COPD ExacerbationsR01HL141264 · NHLBI · NATIONAL JEWISH HEALTH · PI Fabienne Gally · 2019 to 2026
$3.7M
NHLBI NIH HHS R01 HL141264
6 · The paper itself

Abstract

Macrophages are large mononuclear immune cells that participate in host protection, not only by phagocytosing foreign or infected cells and initiating inflammatory responses, but also by contributing to the resolution of inflammation. Chronic Obstructive Pulmonary Disease (COPD) is characterized by increased numbers of macrophages in lung tissue, with altered engulfment capabilities. However, the molecular pathways leading to macrophage dysfunction in COPD remain unclear. Using integrated genetics and genomics approaches, we previously identified Fatty Acid Binding Protein 5 (FABP5) as a key target in the resolution of airway inflammation that exhibits decreased expression in COPD patients. The objective is to define the significance of alveolar macrophage FABP5 by comparing the resolution of inflammation in WT and Fabp5

Indexed as

Fatty Acid-Binding ProteinsMacrophages, AlveolarAnimalsEfferocytosisHaemophilus InfectionsHaemophilus influenzaeHumansInflammationMiceMice, KnockoutNeoplasm ProteinsPulmonary Disease, Chronic ObstructiveFabp5 protein, mouseFatty Acid-Binding ProteinsNeoplasm ProteinsCOPDresolution of inflammation

Identifiers

PMID42335653
PMCPMC13320021

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.