ArticleProceedings of the National Academy of Sciences of the United States of America2026
A broadly conserved gram-positive lipoprotein regulates cell elongation.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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Who cites it
2 citing papers in PubMed.
- The phenotypic landscape of the model firmicuteProceedings of the National Academy of Sciences of the United States of America · 2026Article
- A broadly conserved gram-positive lipoprotein regulates cell elongation.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
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Authors and funding
3 authors.
Funding
Abstract
The cell wall peptidoglycan (PG) protects virtually all bacteria from osmotic lysis and specifies cell shape. Synthesis of this exoskeleton is carried out by enzymes that polymerize glycan strands and transpeptidases that crosslink them into the existing cell wall matrix. In many bacteria, a broadly conserved cell wall synthesis complex known as the Rod complex or elongasome plays an essential role in cell growth. To investigate whether there are undiscovered Rod complex components, we combined high-throughput genetics with AlphaFold-Multimer screens. The two approaches converged on the lipoprotein ClcR (formerly, YerH or CamS). ClcR is broadly conserved among gram-positive bacteria and is predicted to interact with the Rod complex transpeptidases. We find that ClcR contributes to proper cell wall synthesis in
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