ArticleMolecular biology reports2026
Interplay between CDH1 polymorphisms, haplotypes, and genomic repetitive elements in urothelial bladder cancer prognosis.
Article in Molecular biology reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
backgroundUrothelial Bladder Cancer (UBC) remains a significant clinical challenge due to its high morbidity, substantial economic burden, and high recurrence rates. E-cadherin, an important regulator of cell-cell adhesion encoded by the CDH1 gene, is frequently downregulated during malignant progression, serving as a hallmark of invasiveness. This study explored the prognostic significance of CDH1 genetic variants (rs16260 C > A and rs7186053 A > G) and haplotypes, while integrating bioinformatic profiling of repetitive elements. METHODS AND
resultsA cohort of 334 UBC patients was genotyped via qPCR, followed by haplotype reconstruction and association with clinical outcomes. This analysis was complemented by immunofluorescence to illustrate the interplay between tissue invasion levels and CDH1 genetic backgrounds in selected samples. Bioinformatic tools characterized the CDH1 genomic repeat elements landscape. The rs16260 heterozygous genotype was significantly associated with a reduced risk of 1-year recurrence (p < 0.05). Moreover, the CG haplotype emerged as a protective factor against recurrence within two years. Illustrative immunofluorescence analysis confirmed the loss of E-cadherin and epithelial disorganization in muscle-invasive samples compared to non-invasive tumors. Notably, bioinformatic screening revealed a complex architecture of repetitive elements, including novel Alu insertions within Exon 16, indicating potential regulatory hubs.
conclusionOur findings demonstrate that CDH1 polymorphisms and haplotype structures are potential modulators of UBC recurrence. Furthermore, the identification of repetitive elements in crucial genomic segments highlights a new layer of transcriptional regulation, offering promising approaches for the prognostic stratification and molecular targeting of bladder cancer.
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