ReviewMolecular biology reports2026
Telomere biology and telomerase regulation across species: evolutionary insights into aging, longevity, and genome stability.
Review in Molecular biology reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
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0 citing papers in PubMed.
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Telomeres are protective DNA-protein structures at chromosome ends that play a crucial role in maintaining genome stability and regulating cellular aging. Their progressive shortening during cell division is counteracted by telomerase, a ribonucleoprotein enzyme composed of a catalytic subunit namely, telomerase reverse transcriptase catalytic subunit (TERT) and an RNA template i.e., telomerase RNA component (TERC), which restores telomeric repeats. Telomerase activity varies across species and is closely associated with differences in longevity. This review synthesizes current knowledge on telomere biology across diverse taxa, focusing on evolutionary selection patterns, age-related gene expression, and key regulatory mechanisms. By integrating insights from comparative genomics, functional studies, and computational approaches, it highlights both conserved and species-specific factors influencing lifespan and age-related processes. The review also discusses emerging computational frameworks for predicting telomere dynamics and outlines their potential applications in telomere-based therapies, livestock improvement, and conservation biology.
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42334703What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.